Thin Film Transistor Biosensor for Accurate Glucose Detection
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Solution Overview
Problem
Conventional electrochemical biosensors have low reliability due to low measurement sensitivity and accuracy in detecting clinically significant substances like glucose, ketones, and bilirubin in biological samples.
Innovation Solution
A biosensor design incorporating a bio-sensing chip with thin film transistors, a reaction layer, and multiple sub-cells with analysis and reference sensing regions, which improves measurement sensitivity and accuracy by detecting electrochemical signals and correcting them using a reference value.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional electrochemical biosensors are used to measure target substances, then the measurement process is simple, but the measurement sensitivity and accuracy are low
Solution Approach 1:
The biosensor is divided into multiple sub-cells, each containing analysis and reference sensing regions. This segmentation allows independent measurement and correction processes to occur in separate regions, improving measurement precision while maintaining manageable device complexity through modular design
Solution Approach 2:
A reference sensing region is introduced as an intermediary element that provides a baseline measurement. This reference region mediates the measurement process by allowing the system to correct for environmental interference and non-specific binding, thereby improving accuracy without significantly increasing overall device complexity
2Reliability
If conventional biosensors measure only electrochemical signals, then the device structure is simple, but the reliability of measurement results is low
Solution Approach 1:
The reference sensing region provides feedback information about environmental conditions and non-specific effects. This feedback is used to correct the measurements from the analysis sensing region, improving reliability by compensating for sources of error that would otherwise compromise measurement accuracy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances the accuracy of measuring target substances by improving the detection of electrochemical signals and providing corrected measurement values, leading to more reliable results.
Implementation Method 1
configured to measure resistance variation corresponding to characteristics of current and voltage through electrochemical reaction
Implementation Method 2
a gate electrode of the first thin film transistor may contact the reaction layer
Data Source
AI summary
Disclosed herein is a biosensor. The biosensor includes: a mount; a bio-sensing chip disposed on the mount and including at least one thin film transistor; a reaction layer disposed on the bio-sensing chip and including at least one of a biological sample and a biochemical reaction reagent; an upper electrode disposed on an upper surface of the reaction layer and supplying electric signal to the reaction layer; and at least one pad disposed on the bio-sensing chip and electrically connected to the bio-sensing chip. The biosensor can measure voltage-current characteristics in a linear region and a saturation region through examination with respect to a target substance using the thin film transistor.