TGF-beta Peptide Fragments for Skin Collagen Production
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Solution Overview
Problem
Current solutions fail to provide a safe and effective skin collagen production-promoting agent that can prevent wrinkles and sagging by promoting collagen biosynthesis in the skin.
Innovation Solution
A skin collagen production-promoting agent comprising Transforming Growth Factor-beta (TGF-β) and/or its degradation product, acquired by degrading TGF-β with proteases such as trypsin, pancreatin, or papain, is used to increase collagen content in the skin.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If TGF-β is used to promote collagen production, then skin quality improves, but safety problems arise
Solution Approach 1:
The patent applies segmentation by degrading TGF-β into smaller peptide fragments through protease treatment. This divides the large protein molecule (25 kDa) into smaller segments that can be safely absorbed and utilized by the body, reducing the safety concerns associated with administering intact TGF-β while retaining the collagen-promoting biological activity.
Solution Approach 2:
The patent extracts the active collagen-promoting component from the complete TGF-β protein by using proteases to cleave and release specific peptide fragments. This extraction process isolates the beneficial functional segments while removing potentially harmful portions of the protein structure.
2Strength
If collagen production is promoted to prevent wrinkles and sagging, then skin elasticity improves, but the complexity of the solution increases
Solution Approach 1:
The patent employs readily available proteases (trypsin, papain, bromelain) that can be easily obtained and applied in simple dietary or topical formulations. These enzymes naturally degrade TGF-β into active peptides without requiring complex processing equipment or multi-step procedures, thereby achieving collagen promotion through simple, accessible means.
3Quantity of substance
If TGF-β degradation products are used, then collagen content increases, but the manufacturing process becomes more complex
Solution Approach 1:
The patent performs preliminary degradation of TGF-β into active peptide fragments before administration or incorporation into products. By pre-processing TGF-β with proteases to generate the active collagen-promoting fragments in advance, the actual application process becomes simpler and more direct, as the active form is already prepared.
Solution Approach 2:
The patent changes the molecular weight parameter of TGF-β by degrading it into smaller peptide fragments with molecular weights typically below 10 kDa. This parameter change from large protein to small peptides transforms the substance into a form that is more easily absorbed and utilized while maintaining biological activity, and can be achieved through simple enzymatic treatment.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The agent effectively promotes collagen production in the skin, improving skin quality by preventing wrinkles, sagging, dryness, and roughening, with a daily oral ingestion or application of TGF-β or its degradation product showing significant collagen production and skin improvement effects.
Implementation Method 1
a TGF-β degradation product acquired by degrading TGF-β with a protease
Data Source
AI summary
A problem of the present invention is to provide a skin collagen production-promoting agent without safety problems. Another problem of the present invention is to provide a skin collagen production-promoting food or drink product and a skin collagen production-promoting cosmetic product containing such a substance. TGF-β and/or a TGF-β degradation product, which is acquired by degrading TGF-β with a protease such as pepsin, pancreatin, etc., are used as a skin collagen production-promoting agent or the active ingredient of a skin collagen production-promoting food or drink product and a skin collagen production-promoting cosmetic product. The aforementioned TGF-β and/or TGF-β degradation product have an effect of increasing the collagen content of the skin.