D9-THC Naphthoylester Polymorphs for High-Purity THC Isolation
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Solution Overview
Problem
Isolating Δ9-tetrahydrocannabinol (Δ9-THC) from cannabis extracts in high yields and high purity is challenging due to the difficulty in separating it from other cannabinoids, particularly Exo-d9-THC naphthoylester impurities.
Innovation Solution
The development of novel crystalline forms of Δ9-THC naphthoylester, characterized by specific X-ray powder diffraction patterns, which facilitate the crystallization process to expel impurities and enhance purity through seeding and solvent treatment, resulting in higher yields of pure Δ9-tetrahydrocannabinol.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional extraction methods are used to isolate Δ9-THC from cannabis extracts, then the isolation process can be performed with simple equipment, but the purity of Δ9-THC is low due to contamination with other cannabinoids and Exo-d9-THC naphthoylester impurities
Solution Approach 1:
The patent employs parameter changes by utilizing specific solvent systems (hexane/ethyl acetate mixtures) and controlling crystallization conditions (temperature, solvent ratios) to selectively precipitate Δ9-THC naphthoylester in high purity form, separating it from other cannabinoids and impurities through controlled phase transitions
Solution Approach 2:
The invention utilizes phase transitions by inducing crystallization of Δ9-THC naphthoylester from solution through controlled cooling and solvent evaporation, transforming the compound from dissolved state to crystalline solid state, thereby achieving high purity isolation without complex purification equipment
2Manufacturing precision
If extensive purification techniques are applied to remove Exo-d9-THC naphthoylester impurities, then the purity of Δ9-tetrahydrocannabinol can be increased, but the productivity and yield are reduced due to multiple processing steps
Solution Approach 1:
The patent applies preliminary action by performing selective crystallization of Δ9-THC naphthoylester early in the process to pre-concentrate and purify the target compound before final hydrolysis, thereby reducing the need for extensive post-purification steps and maximizing yield
Solution Approach 2:
The invention uses selective extraction principles by utilizing the differential solubility of Δ9-THC naphthoylester compared to Exo-d9-THC naphthoylester and other cannabinoids in specific solvent systems, allowing the target compound to be selectively precipitated and separated in high purity form
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The novel crystalline forms of Δ9-THC naphthoylester effectively reduce Exo-d9-THC naphthoylester impurities, enabling the production of Δ9-tetrahydrocannabinol in greater purity and yield without extensive purification techniques.
Implementation Method 1
novel crystalline forms of Δ9-THC naphthoylester, characterized by specific X-ray powder diffraction patterns, which facilitate the crystallization process to expel impurities and enhance purity
Implementation Method 2
crystalline D9-THC-naphthoylester characterized by an X-ray powder diffraction pattern having at least one peak selected from the group consisting of 5.81°, 10.78°, 11.61°, 13.55°, 15.58°, 16.18°, 17.86°, 18.43°, 19.10°, 19.49°, 20.31°, 20.82°, 21.61°, 21.80°, 22.87°, 23.28°, 24.19°, 26.38°, 29.30°, 31.08°, and 32.02° 2θ
Data Source
AI summary
The present disclosure relates to polymorphs of D9-THC-naphthoylester for the preparation of D9-Tetrahydrocannabinol in high yields and high purity, methods of preparing the D9-Tetrahydrocannabinol, and compositions comprising the D9-Tetrahydrocannabinol.