THCV Isolation via Distillation and Flash Chromatography

The patent applies parameter changes by optimizing distillation conditions (temperature, pressure, flow rate) to enhance THCV enrichment efficiency. Specifically, the method uses controlled temperature gradients and pressure adjustments during distillation to selectively vaporize and condense THCV, achieving high-purity separation without requiring multiple costly processing steps. This optimization of physical parameters directly improves both separation efficiency and cost-effectiveness

The patent replaces traditional mechanical separation methods with a combined distillation-chromatography approach. Instead of relying on complex mechanical filtration or centrifugation systems, the invention uses thermal energy-driven distillation followed by chromatographic separation, substituting mechanical complexity with thermodynamic and chemical principles that achieve superior purification at lower cost

The patent applies segmentation by dividing the separation process into two distinct stages: first, distillation for rapid bulk enrichment of THCV, and second, flash chromatography for high-precision purification. This segmentation allows the process to achieve both high productivity in the first stage and high purity in the second stage, resolving the contradiction between speed and precision

The patent introduces an intermediary step between distillation and final purification. The distillation process creates an intermediate distillate that is enriched in THCV but still contains other cannabinoids. This intermediate product then serves as the feedstock for flash chromatography, which performs the final high-precision separation. The intermediary step allows efficient mass transfer in the first stage while enabling precise purification in the second stage