Therapeutic Gas Delivery Device With Layered Activation
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Solution Overview
Problem
Conventional devices for delivering therapeutic gases to targeted sites are inadequate in sustaining a useful and localized dose over treatment duration, lacking in ease of use and safety.
Innovation Solution
A device comprising a fibrous holding layer with a gas-donor composition between a water-permeable and gas-permeable layer, allowing water to activate the gas-donor composition and deliver therapeutic gases like NO, O2, CO2, H2S, or CO to a treatment site, with features for expelling byproducts and ensuring safety.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If conventional devices (pads and patches) are used to deliver therapeutic gas, then the device structure is simple, but the treatment duration is insufficient and the localized dose cannot be sustained
Solution Approach 1:
The device is divided into three distinct functional layers: a water-permeable layer for water intake, a gas-donor composition layer for therapeutic gas generation, and a gas-permeable layer for gas delivery. This segmentation allows each layer to perform its specific function optimally, enabling sustained gas delivery over extended treatment durations while maintaining manageable device complexity through modular design.
Solution Approach 2:
The gas-donor composition is pre-loaded into the device in an inactive state, ready to generate therapeutic gas upon contact with water. This preliminary preparation ensures that the device can immediately begin sustained gas delivery when activated by water contact, eliminating the need for external gas sources during treatment and extending the effective treatment duration.
2Quantity of substance
If systemic exogenous delivery of nitric oxide is achieved through nitroglycerin administration, then NO delivery is achieved, but enzyme and co-factor pathways are rapidly exhausted resulting in drug tolerance and physiological complications
Solution Approach 1:
The device delivers nitric oxide locally at the treatment site through the gas-permeable layer rather than systemically through the bloodstream. This localized delivery concentrates the therapeutic effect at the target area while avoiding systemic circulation of high NO concentrations, thereby preventing enzyme exhaustion, drug tolerance, and physiological complications such as hypotension and free radical cell damage.
Solution Approach 2:
The gas-donor composition acts as an intermediary that converts water into therapeutic gas on-demand at the treatment site. This intermediary mechanism replaces the need for systemic nitroglycerin administration and its associated metabolic pathways, providing reliable and sustained NO delivery without enzyme exhaustion or drug tolerance issues.
3Ease of operation
If conventional devices are used for therapeutic gas delivery, then the device is simple to manufacture, but ease of use and safety are inadequate
Solution Approach 1:
The device integrates multiple functions into a single unit: the water-permeable layer simultaneously serves as both the activation mechanism (water intake) and the structural interface for application. The gas-donor composition provides both storage and on-demand generation of therapeutic gas. This multi-functionality simplifies the user experience (apply once, sustained delivery) while the modular layer structure maintains manufacturing feasibility through standardized production processes.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device provides a sustained therapeutic gas-rich environment, reducing fibrosis and scar formations while maintaining anti-inflammatory, anti-thrombotic, and antimicrobial properties, enhancing ease of use and safety.
Implementation Method 1
the gas-donor composition is configured to release a therapeutic gas upon contact with the water
Implementation Method 2
receive water entering the device through the water-permeable layer
Implementation Method 3
deliver a therapeutic gas through the gas-permeable layer to an adjacent treatment site
Data Source
AI summary
The disclosure concerns various devices implemented to provide a therapeutic gas rich environment to promote healing, reduce fibrosis and scar formations while maintaining anti-inflammatory, anti-thrombotic, antimicrobial, and vasodilating properties. The device generally includes a gas-donor composition that is embedded within a fibrous holding layer. Coupled to one side of the fibrous holding layer is a water-permeable layer and coupled to an opposite side of the fibrous holding layer is a gas-permeable layer. The water-permeable layer is configured to receive and communicate water to the gas-donor composition, wherein upon contact with the water, the gas-donor composition is configured to deliver a therapeutic gas through the gas-permeable layer to a treatment site of a subject.