Cancer Therapy Delivery Assembly With Jumper Priming

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Solution Overview

Problem

Existing cancer therapy delivery systems face challenges in efficiently preparing and delivering radioactive microspheres due to complex assembly steps and potential microsphere dropout in small-diameter catheters, leading to inefficiencies and increased risk of air introduction during priming.

Innovation Solution

A cancer therapy delivery system with improved flow paths and features, including a jumper device providing a direct fluid flow path between conduits, deployment restriction devices, and reduced component count, simplifying priming operations and ensuring minimal microsphere dropout.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a complex assembly system with multiple components is used for delivering radioactive microspheres, then the delivery capability is improved, but the preparation time and operational complexity increase significantly

Engineering Contradiction:

Improvemicrosphere delivery reliabilityVSAvoidpreparation time

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The system is divided into modular components including a removable jumper device, separate inflow and outflow conduits, and distinct assembly stages (priming assembly vs. delivery assembly), allowing independent preparation and verification of each module before final integration

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The jumper device provides a preliminary flow path that enables priming and air bubble removal before the actual microsphere delivery components are connected, allowing the system to be prepared in advance without risking microsphere dropout or air introduction

Inventive Principle:

Principle #10Preliminary action

2Manufacturing precision

If small-diameter catheters are used for precise tumor targeting, then the treatment precision is improved, but microsphere dropout in the catheter increases

Engineering Contradiction:

Improvetumor targeting precisionVSAvoidmicrosphere dropout

Core Design Contradiction:

Manufacturing precisionVSLoss of substance

Solution Approach 1:

The system performs preliminary priming and air bubble removal through the jumper device before connecting the microsphere delivery components, ensuring the small-diameter catheter is completely filled with carrier fluid and free of air bubbles that would cause microsphere dropout

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The jumper device acts as an intermediary flow path that mediates between the carrier fluid reservoir and the microsphere delivery system, allowing fluid dynamics to be established in a larger diameter path before transitioning to the small-diameter catheter, thereby preventing microsphere entrapment

Inventive Principle:

Principle #24Intermediary (Mediator)

3Reliability

If traditional priming procedures are used with multiple connection steps, then complete system priming is achieved, but the risk of air introduction increases

Engineering Contradiction:

Improvesystem priming completenessVSAvoidair introduction risk

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The jumper device merges the inflow and outflow pathways into a single continuous flow loop during priming, allowing carrier fluid to circulate and displace air bubbles throughout the entire system in one continuous operation, reducing the number of connection/disconnection steps that could introduce air

Inventive Principle:

Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Facilitates faster and more reliable preparation of the system, reduces the risk of air introduction, and allows for use with small-diameter catheters, enhancing the delivery of radioactive microspheres to target sites.

Implementation Method 1

a removable jumper device configured to provide a direct fluid flow path between the inflow conduit and the outflow conduit

Methodology Applied

Scientific EffectFluid flow:

Implementation Method 2

the deployment restriction device can be configured to limit vertical travel of the inflow conduit and the outflow conduit

Methodology Applied

Scientific EffectMechanical constraint:

Implementation Method 3

the cap can be configured to be attached to a bottom end of the fluid injector and withdrawal assembly using a pressure-fit mechanism

Methodology Applied

Scientific EffectFriction: Friction

Data Source

PatentUS20250332444A1Cancer therapy delivery systems and methods

Publication Date: 2025.10.30 BOSTON SCIENTIFIC SCIMED INC

AI summary

Embodiments herein relate to cancer therapy delivery systems with improved flow paths and features for preparing the same for use. In an embodiment, a cancer therapy delivery system is included having a carrier fluid delivery device and a first fluid line, wherein the first fluid line is in fluid communication with the carrier fluid delivery device. The system can also include a fluid injector and withdrawal assembly including an inflow conduit and an outflow conduit. The fluid injector and withdrawal assembly is in fluid communication with the first fluid line and a second fluid line. The system can also include a fluid delivery catheter in fluid communication with the second fluid line. The system can also include a jumper device configured to provide a direct fluid flow path between the inflow conduit and the outflow conduit. Other embodiments are also included herein.