Patient Targeted Therapy Platform Grouping Genetic Data

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Solution Overview

Problem

Current technologies lack an efficient method for grouping individuals based on genetic information and characterization parameters to develop targeted therapies tailored to specific groups or individuals.

Innovation Solution

A platform is developed that utilizes genetic information and characterization parameters to group individuals, allowing for the identification and development of targeted therapies specific to these groups or individuals.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If genetic information and characterization parameters are used to group individuals for targeted therapy development, then therapy customization and effectiveness are improved, but system complexity and data processing requirements increase

Engineering Contradiction:

Improvetherapy effectivenessVSAvoidsystem complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The platform segments the therapy development process into distinct modules: genetic information analysis, characterization parameter assessment, individual grouping, and targeted therapy selection. This modular segmentation manages system complexity by breaking down the complex task of personalized therapy development into manageable, independent components that can be processed separately and integrated systematically.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The platform acts as an intermediary system between raw genetic/characterization data and clinical therapy decisions. It mediates the complex data processing by serving as a computational bridge that transforms multidimensional genetic and phenotypic data into actionable patient groupings and therapy recommendations, reducing the complexity burden on both data collection and clinical decision-making processes.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Measurement precision

If multiple characterization parameters and genetic information are analyzed, then grouping precision and therapy targeting are improved, but data processing time and computational resources increase

Engineering Contradiction:

Improvegrouping precisionVSAvoiddata processing time

Core Design Contradiction:

Measurement precisionVSLoss of time

Solution Approach 1:

The platform performs preliminary actions by pre-processing and normalizing genetic information and characterization parameters before actual grouping analysis. It pre-establishes data quality standards, performs initial filtering and validation, and prepares data structures in advance, thereby reducing the computational burden and processing time during the actual patient grouping and therapy matching phases.

Inventive Principle:

Principle #10Preliminary action

3Adaptability or versatility

If individual-specific therapies are developed based on genetic makeup, then treatment specificity and patient outcomes are improved, but development cost and resource requirements increase

Engineering Contradiction:

Improvetherapy specificityVSAvoidresource requirements

Core Design Contradiction:

Adaptability or versatilityVSQuantity of substance

Solution Approach 1:

The platform merges individuals with similar genetic profiles and characterization parameters into treatment groups, enabling shared therapy development resources. By combining data and samples from multiple individuals with similar profiles, the system achieves individualized therapy specificity while pooling resources to reduce overall development costs and resource requirements through group-based analysis and validation.

Inventive Principle:

Principle #5Merging (Combining)

Data Source

PatentUS20250140372A1Systems and methods for patient targeted therapy development

Publication Date: 2025.05.01 FLAGSHIP PIONEERING INNOVATIONS VI LLC

AI summary

Described herein are platforms for use in targeted therapy development for an individual or group of individuals. Targeted therapy development as described herein comprises developing a therapeutic or therapeutic modality that is specific to or customized to an individual or group of individuals.