Thermal Cycler Heated Cover Positioning via Mechanical Sensor

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Solution Overview

Problem

Current thermal cycler systems face challenges in efficiently detecting and ensuring the correct positioning of sample holders without user intervention, as existing methods are complex, costly, or require expensive sensors and imaging systems.

Innovation Solution

A thermal cycler system with a sample block, a heated cover, and a drive assembly that moves the cover lid and heated cover to ensure proper contact with the sample holder, utilizing sensors to detect the position and force applied, allowing for automated operation without user interaction.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Difficulty of detecting and measuring

If imaging systems or barcode readers are used to detect sample holder presence, then detection capability is improved, but device complexity and cost increase

Engineering Contradiction:
Improvesample holder detection capabilityVSAvoidsystem complexity
Core Design Contradiction:
Difficulty of detecting and measuringVSDevice complexity

Solution Approach 1:

The patent replaces complex optical detection systems (imaging systems, barcode readers) with a simple mechanical sensor that detects the presence of the sample holder through direct physical contact or proximity sensing. This mechanical approach provides sufficient detection capability while dramatically reducing device complexity and cost.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent employs a simple, inexpensive mechanical sensor rather than expensive optical detection systems. This cost-effective sensing element provides the necessary detection function without the high cost and complexity of imaging systems or barcode readers.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

2Measurement precision

If load cells are embedded to detect sample holder presence, then detection accuracy is improved, but device complexity and cost increase

Engineering Contradiction:
Improvesample holder presence detection accuracyVSAvoidsystem complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent replaces precision load cells with a simpler mechanical sensor system that achieves sufficient detection accuracy through mechanical means such as switches, levers, or proximity sensors that respond to the presence or absence of the sample holder without requiring sophisticated force measurement.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The mechanical sensor system is designed to be self-actuating through the natural presence or absence of the sample holder, eliminating the need for complex measurement systems. The sample holder itself triggers the detection mechanism through its own weight or position.

Inventive Principle:
Principle #25Self-service

3Extent of automation

If automated feedback controls are implemented, then automation efficiency is improved, but device complexity increases

Engineering Contradiction:
Improveautomation levelVSAvoidcontrol system complexity
Core Design Contradiction:
Extent of automationVSDevice complexity

Solution Approach 1:

The patent implements a simple feedback control mechanism where a mechanical sensor detects sample holder presence and directly signals the controller to initiate or terminate the thermal cycling process. This straightforward feedback loop achieves effective automation without complex control algorithms or multiple sensing elements.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The system is designed to automatically detect and respond to sample holder presence without user intervention. The mechanical sensor and controller work together to self-regulate the thermal cycling process based on the detected state, eliminating the need for manual operation while maintaining simplicity.

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system ensures efficient and automated thermal cycling by accurately detecting the sample holder's presence and applying the necessary force, enhancing the integration with lab automation systems and reducing costs associated with complex detection methods.

Implementation Method 1

The heated cover is configured to move in a direction toward the sample block from a raised position to a first lowered position, in which the heated cover contacts the sample holder when the sample holder is received by the sample block

Methodology Applied
Scientific EffectMechanical Force: Mechanical Force

Implementation Method 2

a thermal cycler system for use with a sample holder configured to receive a plurality of samples includes a sample block configured to receive the sample holder, and a heated cover

Methodology Applied
Scientific EffectThermal Conduction: Conduction (thermal)

Data Source

PatentUS11110462B2Systems and methods for a thermal cycler heated cover
Publication Date: 2021.09.07 LIFE TECHNOLOGIES CORP
  • US11110462B2 patent drawing
  • US11110462B2 patent drawing
  • US11110462B2 patent drawing

AI summary

A thermal cycler system for use with a sample holder configured to receive a plurality of samples includes a sample block configured to receive the sample holder, a cover lid configured to move in a direction toward the sample block from an open position to a closed position, a heated cover operatively coupled to the cover lid and configured to move in a direction toward the sample block from a raised position to a first lowered position, in which the heated cover contacts the sample holder when the sample holder is received by the sample block, and a drive assembly including a motion guide configured to move in a direction toward the sample block from a first position, wherein the cover lid is in the open position and the heated cover is in the raised position, to a second position, wherein the cover lid is in the closed position.