Thermal Vascular Modulation for Localized Blood Pressure Control

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Solution Overview

Problem

Current methods are inadequate for effectively treating hypertension or hypotension in localized parts of the vascular system, as they often lead to damage to blood vessels and do not address the root cause of blood pressure imbalances in specific regions like the pulmonary or renal arteries.

Innovation Solution

A system utilizing a constriction device with a cooling surface to reduce blood pressure in the pulmonary artery and a heating surface to dilate the renal artery, combined with a control unit and sensors to regulate temperature and mechanical or hydraulic mechanisms for precise blood vessel modulation, along with the option of electrical stimulation to treat aneurysms.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional methods are used to treat hypertension or hypotension in localized vascular regions, then blood pressure imbalances may be addressed, but damage to blood vessels occurs and the root cause is not effectively treated

Engineering Contradiction:
Improvetreatment effectivenessVSAvoidblood vessel damage
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies local thermal treatment to specific regions of blood vessels affected by hypertension or hypotension. The thermal element is positioned at the exact location of the vascular problem, allowing localized vasomodulation without affecting other parts of the vascular system, thereby treating the root cause while avoiding unnecessary damage to healthy vessels.

Inventive Principle:
Principle #3Local quality

Solution Approach 2:

The patent changes the physical parameter of temperature to induce vasomodulation. By controlling the thermal element to deliver specific temperature ranges, the system achieves vasoconstriction or vasodilation effects that address blood pressure imbalances without the mechanical trauma associated with conventional surgical interventions.

Inventive Principle:
Principle #35Parameter changes

2Manufacturing precision

If thermal elements are used to treat localized hypertension or hypotension, then precise blood pressure control in affected areas is achieved, but the system complexity increases

Engineering Contradiction:
Improveblood pressure control precisionVSAvoidsystem complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The patent employs a multi-functional device that integrates thermal elements, sensors, and control mechanisms into a single system capable of treating both hypertension and hypotension. The same device can adapt its function based on the detected condition, reducing the need for multiple separate treatments and simplifying the overall therapeutic approach.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent incorporates sensors that continuously monitor blood pressure or flow parameters and feed this information back to the control system. This closed-loop feedback mechanism enables automatic adjustment of thermal element activation, achieving precise blood pressure control while minimizing manual intervention and reducing operational complexity.

Inventive Principle:
Principle #23Feedback

3Stress or pressure

If cooling surfaces are used to constrict blood vessels and reduce blood pressure, then localized hypertension is treated, but the risk of tissue damage from extreme temperatures increases

Engineering Contradiction:
Improveblood pressure reductionVSAvoidtissue damage risk
Core Design Contradiction:
Stress or pressureVSObject-affected harmful factors

Solution Approach 1:

The patent implements protective measures by designing the cooling surface to operate within safe temperature ranges that prevent tissue damage. The system includes temperature monitoring and control mechanisms that activate before dangerous temperature levels are reached, cushioning against potential harm while still achieving the desired vasoconstriction and blood pressure reduction effects.

Inventive Principle:
Principle #11Beforehand cushioning (Prior cushioning)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This system allows for localized treatment of hypertension and hypotension, reducing the risk of vessel damage by precisely controlling blood pressure in affected areas, thereby preventing organ damage and promoting healthy blood flow.

Implementation Method 1

a cooling surface able to cool said passageway to restrict said passageway thereby reducing the blood pressure distal to said restriction

Methodology Applied
Scientific EffectCooling: Cooling

Implementation Method 2

a heating surface able to heat said passageway to dilate said passageway thereby increasing the blood pressure distal to said restriction

Methodology Applied
Scientific EffectHeating: Heating

Implementation Method 3

a thermal element configured to conduct thermal energy between the thermal element and a desired region of the vessel wall to elicit the localized vasomodulation of the vessel at the desired region

Methodology Applied
Scientific EffectThermal conduction: Conduction (thermal)

Data Source

PatentEP2214607B1System for thermal treatment of hypertension, hypotension or aneurysm
Publication Date: 2021.09.22 IMPLANTICA PATENT LTD
  • EP2214607B1 patent drawingFigure 1A~1B
  • EP2214607B1 patent drawingFigure 2A~2B
  • EP2214607B1 patent drawingFigure 3a~3b

AI summary

In accordance with the present invention, there is provided a system for treating a patient with local hypertension, comprising a hypertension treatment device adapted to have at least one surface of the device attached to the blood flow passageway, wherein said surface comprising a cooling surface able to cool said passageway to restrict said passageway thereby reducing the blood pressure distal to said restriction. In accordance with a another aspect of the present invention, there is provided a system for treating a patient with aneurysm, comprising a aneurysm treatment device adapted to have at least one surface of the device attached to the blood flow passageway, wherein said surface comprising a cooling surface able to cool said passageway to restrict said passageway thereby treating said aneurysm. In accordance with a second aspect of the present invention, there is provided a system for treating a patient with hypotension, comprising a hypotension treatment device adapted to have at least one surface of the device attached to the blood flow passageway, wherein said surface comprising a heating surface able to heat said passageway to dilate said passageway thereby increasing the blood pressure distal to said restriction.