Thermoplastic Bone Wrap for Guided Regeneration Containment
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Solution Overview
Problem
Existing methods struggle to effectively contain bone regenerative therapeutics at the site of bone defects, leading to challenges in guided bone regeneration and unwanted ectopic bone formation in surrounding tissues.
Innovation Solution
The use of thermoplastic sleeves wrapped around bone defects, combined with ultrasonic energy to mold and weld the thermoplastic to the bone, providing containment and allowing for controlled delivery of osteogenic therapeutics while preventing tissue encroachment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If bone regenerative therapeutics are delivered without containment, then the therapeutic can reach surrounding tissues, but the therapeutic cannot be contained at the site of intended action leading to unwanted ectopic bone formation
Solution Approach 1:
A thin film barrier is applied to contain the bone regenerative therapeutic at the site of intended action. The barrier prevents diffusion of the therapeutic into surrounding tissues, thereby eliminating ectopic bone formation while maintaining reliable containment at the defect site.
Solution Approach 2:
The treatment site is segmented by introducing a barrier that divides the therapeutic delivery zone from surrounding tissues. This segmentation creates a controlled environment where the therapeutic acts only on the intended bone defect without affecting adjacent structures.
2Reliability
If a barrier is introduced to contain the therapeutic, then the therapeutic is contained at the site of action, but the barrier may obstruct imaging of the bone region
Solution Approach 1:
The barrier material is designed with specific radiological properties that allow it to be transparent or minimally interfering to common bone imaging modalities such as X-ray, CT, and fluoroscopy. This enables maintaining containment functionality while preserving unobstructed imaging capability for monitoring bone regeneration.
3Reliability
If a barrier is used to contain the therapeutic, then the therapeutic is contained, but the barrier may prevent vascular ingrowth and nutrient exchange
Solution Approach 1:
The barrier is constructed as a porous structure with controlled pore sizes that allow vascular ingrowth and nutrient diffusion while maintaining the containment function. The porosity enables biological integration and sustains the bone regenerative process by permitting essential物质 exchange between the contained therapeutic environment and surrounding tissues.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method ensures uniform and stable treatment of bone defects, facilitating bone regeneration with controlled drug delivery and preventing unwanted bone formation in surrounding tissues, while allowing unobstructed imaging and vascular ingrowth.
Implementation Method 1
heat (e.g., provided via one or more of ultrasound energy) is used to mold the thermoplastic to the bone
Implementation Method 2
ultrasonic devices configured to deliver ultrasound energy to the contained bone region is utilized to provide efficient thermoforming of the thermoplastic to the bone
Implementation Method 3
heat (e.g., provided via one or more of ultrasound energy) is used to mold the thermoplastic to the bone
Implementation Method 4
a device that combines localized heat with mechanical pressure for thermowelding of a thermoplastic to bone
Data Source
AI summary
Provided herein are devices, systems, and methods of treating bone defects by wrapping thermoplastics around bone and molding thermoplastic to bone. Also provided herein are a sonotrode coupler and system used to perform the method. The technology provides devices, systems, and methods for containment of graft materials, matrices, and bone regenerative therapeutics and prevents surrounding tissue encroachment for guided bone regeneration.