Thermoreversible Hydrogel Compositions for Cardiac Stem Cell Retention
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods for delivering therapeutic stem cells to damaged cardiac tissue are inefficient, leading to uncontrolled spreading and potential adverse effects, while existing hydrogels lack the mechanical properties to withstand the beating environment and maintain cell viability.
Innovation Solution
A biodegradable thermoreversible hydrogel is used to embed stem cells, which adheres to the scar site beneath the pericardium, providing a supportive scaffold that maintains cell viability and controlled release, with adjustable mechanical properties to withstand heart contractions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If stem cells are delivered to damaged cardiac tissue using current methods, then cell delivery is achieved, but the cells spread uncontrolled and cause potential adverse effects
Solution Approach 1:
The patent uses an injectable hydrogel as an intermediary carrier system to deliver stem cells to the damaged cardiac tissue. The hydrogel acts as a temporary scaffold that confines the cells at the injection site, preventing uncontrolled spreading while maintaining cell viability and facilitating controlled release over time.
2Reliability
If hydrogels are used to embed stem cells, then cell retention is improved, but the hydrogel lacks mechanical properties to withstand heart contractions
Solution Approach 1:
The patent modifies the hydrogel's physical and chemical parameters to achieve both cell retention and mechanical durability. The hydrogel formulation includes specific polymer ratios, cross-linking densities, and structural characteristics that enable it to withstand the mechanical stress of heart contractions while maintaining its ability to embed and retain stem cells.
3Reliability
If hydrogels are used as supportive scaffold, then cell viability is maintained, but the hydrogel may be washed out due to weak mechanical properties
Solution Approach 1:
The patent employs a composite hydrogel material that combines multiple polymer components with different functional properties. This composite structure provides both the biochemical support needed for cell viability and the mechanical strength required to resist washout by body fluids, creating a stable scaffold that persists long enough to facilitate tissue regeneration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The hydrogel effectively retains stem cells at the treatment site for prolonged periods, enhancing therapeutic efficacy by preventing systemic spread and ensuring controlled cell delivery and duration.
Implementation Method 1
biodegradable thermoreversible hydrogels
Implementation Method 2
adheres to the scar site beneath the pericardium
Data Source
AI summary
The present invention provides methods and compositions for treating damage to the heart tissue. In particular, the present invention provides pharmaceutical compositions comprising stem cells embedded in biocompatible thermoreversible hydrogels and use thereof in treating myocardium infarction.