Novel Thioamide Derivatives for Parasitic Control

The patent applies parameter changes by systematically varying the chemical structure of thioamide derivatives through different substituents (R1-R11) at specific positions on the heteroaryl ring and side chains. This structural optimization enhances parasitic control activity while simultaneously improving safety profiles for warm-blooded species, fish, and plants through careful selection of substituent groups that modify pharmacokinetic and toxicological properties.

The invention creates composite molecular structures by combining a core heteroaryl-thioamide framework with various functional substituent groups (alkyl, haloalkyl, aryl, heteroaryl, alkoxy, amino groups, and their substituted variants). This composite approach allows the molecule to achieve both high parasitic activity and improved safety by integrating multiple functional moieties that work synergistically.

The patent segments the molecular structure into distinct functional regions: a core heteroaryl ring system (positions P-Q-R-S-T), multiple substitutable positions (R1-R11) that can be independently optimized, and side chain regions (R6-R11 with various functional groups). This segmentation allows systematic development of analogs by modifying specific segments while maintaining the active pharmacophore, thereby managing structural complexity through modular design.

The invention creates a universal heteroaryl-thioamide scaffold that can serve multiple pesticidal functions against different parasite types (endoparasites and ectoparasites). The core structure with its multiple substitutable positions provides a multi-functional platform where different substituent combinations can target various parasite species and modes of action, reducing the need for entirely separate compound classes.