Thiolated Compound Compositions for Vaginal Tissue Elasticity
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Solution Overview
Problem
Current methods for enhancing vaginal and perineal tissue elasticity during pregnancy are inadequate in preventing lacerations and associated complications such as pain, dyspareunia, and urinary incontinence, as existing treatments like episiotomy and perineal massage show limited effectiveness in reducing severe trauma and improving tissue extensibility.
Innovation Solution
Compositions combining thiolated compounds and esters of organic acids, applied topically in the form of creams, ointments, or gels, which synergistically increase tissue elasticity and elastic recovery by breaking and reforming disulfide bonds, thereby improving the extensibility of vaginal and perineal tissues.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If episiotomy is performed to decrease spontaneous lacerations, then the rate and severity of lacerations are reduced, but dyspareunia and rectal incontinence occur
Solution Approach 1:
The patent applies parameter changes by modifying the chemical structure of compounds to create thiolated derivatives with enhanced elasticizing activity. These compounds change the physical-chemical parameters of tissue proteins, specifically targeting disulfide bonds to improve tissue elasticity and extensibility, thereby preventing lacerations without causing the harmful side effects of episiotomy
Solution Approach 2:
The patent uses composite materials by combining thiolated compounds with specific esters of organic acids in defined ratios. This composite formulation creates a synergistic effect where the thiolated compound breaks disulfide bonds to increase extensibility, while the esters provide emollient properties and support tissue elasticity, achieving both laceration prevention and avoidance of dyspareunia
2Strength
If thiolated compounds are used to break disulphur bonds and increase extensibility, then tissue elasticity is improved, but the primary and secondary structures of proteins are unaffected which limits the extent of elasticizing
Solution Approach 1:
The patent applies local quality by selectively targeting specific disulfide bonds in tertiary and quaternary protein structures while leaving primary and secondary structures intact. This localized action on specific bond types allows for controlled modification of tissue elasticity without disrupting the fundamental protein architecture, achieving enhanced extensibility while maintaining structural integrity
3Object-affected harmful factors
If perineal massage is performed to improve extensibility of perineal tissues, then the incidence of trauma requiring suturing is reduced, but the incidence of 1st or 2nd degree perineal tears and 3rd to 4th degree perineal trauma shows no difference
Solution Approach 1:
The patent applies preliminary action by administering thiolated compounds and esters of organic acids during pregnancy to pre-condition the perineal tissues before delivery. This preliminary treatment breaks disulfide bonds and increases tissue extensibility in advance, creating a more resilient tissue structure that can better withstand the stresses of delivery and prevent lacerations of all degrees
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compositions significantly enhance the elastic properties of vaginal and perineal tissues, reducing the incidence of lacerations and associated complications during delivery, as demonstrated by clinical studies showing improved elasticity and reduced trauma rates.
Implementation Method 1
thiolated compounds, both those provided with free SH groups, and those with the S— atom blocked by a functional group, have the capability to decrease the rigidity of protein structures, by breaking the disulphur bonds
Implementation Method 2
the two SH free groups may further interact and form an —SS— bridge
Data Source
AI summary
Compositions for improving the elasticity of the vagina and of the perineum during the last trimester of pregnancy, include combining a thiolated compound or mixture thereof with an ester of organic acid or mixture thereof. The compositions according to the present invention improve the elastic properties of the vaginal and/or perineal tissues in terms both of increased extensibility and faster elastic recovery. The compositions according to the present invention may decrease risk of trauma of perineal tissues during delivery, as well as risk of rectal or bladder incontinence as a post-partum short/medium/long term complication.