Thiopyridinone Composition pH Control for Thermal Stability

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Solution Overview

Problem

Thiopyridinone compounds used in compositions for skin depigmentation are prone to destabilization over time, especially under elevated temperatures.

Innovation Solution

A composition comprising thiopyridinone compounds, a pH adjusting agent, and water, with a pH range of 4.5 to 6.5, stabilizes the thiopyridinone compounds, enhancing their stability even under elevated temperatures.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If thiopyridinone compound is used in composition for skin depigmentation, then depigmenting effect is improved, but stability of the compound deteriorates under elevated temperature

Engineering Contradiction:

Improvedepigmenting effectVSAvoidstability of thiopyridinone compound

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent applies parameter changes by adjusting the pH of the composition to a specific range (4.5-6.5) to stabilize the thiopyridinone compound. This chemical parameter modification prevents destabilization under elevated temperatures while maintaining the compound's depigmenting efficacy, directly resolving the contradiction between stability and effectiveness

Inventive Principle:

Principle #35Parameter changes

2Duration of action of stationary object

If thiopyridinone compound is stored for long period under elevated temperature, then shelf life is extended, but compound stability deteriorates

Engineering Contradiction:

Improveshelf lifeVSAvoidcompound stability

Core Design Contradiction:

Duration of action of stationary objectVSStability of the object's composition

Solution Approach 1:

The patent implements preliminary anti-action by pre-adjusting the pH of the composition to 4.5-6.5 before storage, which creates a protective chemical environment that prevents thermal destabilization. This proactive pH control counteracts the destabilizing effect of elevated temperatures during long-term storage, enabling extended shelf life without compromising compound stability

Inventive Principle:

Principle #9Preliminary anti-action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition maintains the stability and bioavailability of thiopyridinone compounds, providing enhanced depigmenting or whitening effects over extended periods, including at elevated temperatures.

Implementation Method 1

A composition comprising: (1) at least one compound selected from compounds of formula (I)... (2) at least one pH adjusting agent; and (3) water, wherein the pH of the composition is from 4.5 to 6.5

Methodology Applied

Scientific EffectpH control:

Data Source

PatentUS20250367096A1Stabilization of thiopyridinone compound and composition comprising same

Publication Date: 2025.12.04 LOREAL SA

AI summary

A composition contains: (1) at least one thiopyridinone compound; (2) at least one pH adjusting agent, and (3) water. The pH of the composition is from 4.5 to 6.5. A composition including (1) thiopyridinone compound(s) can be provided with increased stability of the (1) thiopyridinone compound(s) over time, in particular even when the composition is maintained for a relatively long period of time under elevated temperature.