Thixotropic Ablative Gel for Cardiac Tissue Targeting
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Solution Overview
Problem
Current treatments for cardiac diseases, such as arrhythmias and hypertension, using systemic beta-receptor blockade cause indiscriminate effects on cardiac structures, leading to severe side effects and complications.
Innovation Solution
A composition comprising an ablative agent and excipient, formulated as a viscous thixotropic gel, is delivered via a delivery system to target specific cardiac tissues, allowing precise neuromodulation and ablation with minimal migration and side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If systemic beta-receptor blockade is used to treat cardiac diseases, then therapeutic effect on cardiac muscle is improved, but side effects on other cardiac structures and organs increase
Solution Approach 1:
The patent applies local quality by transitioning from systemic to localized treatment. The ablation catheter delivers therapeutic energy (radiofrequency, microwave, or ultrasonic) directly to specific cardiac tissues through targeted catheter positioning, enabling selective treatment of arrhythmogenic substrates while preserving other cardiac structures. This localized energy delivery achieves therapeutic effects on cardiac muscle without the widespread side effects of systemic pharmacologic agents.
Solution Approach 2:
The patent segments the cardiac treatment approach by dividing the heart into distinct treatable regions. The catheter system enables selective ablation of specific cardiac segments or regions harboring arrhythmia substrates, rather than treating the entire cardiac system. This segmentation allows precise targeting of pathological tissues while sparing healthy cardiac structures from harmful effects.
2Reliability
If ablation is performed to treat arrhythmias, then arrhythmia control is improved, but risk of damaging surrounding healthy tissues increases
Solution Approach 1:
The patent implements feedback mechanisms through intracardiac electroanatomic mapping and real-time monitoring during ablation procedures. The catheter system continuously monitors electrical activity and tissue characteristics, providing feedback that guides energy delivery and prevents overheating or excessive tissue damage. This feedback control ensures arrhythmia substrates are effectively ablated while maintaining safety margins around healthy tissues.
Solution Approach 2:
The patent applies dynamics by using adjustable and controllable energy delivery parameters. The ablation catheter system allows dynamic modulation of energy power, duration, and application pattern based on real-time tissue response. This dynamic control enables precise titration of ablation energy to achieve complete arrhythmia substrate elimination while preventing thermal damage to surrounding healthy structures through adaptive parameter adjustment.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables precise treatment of cardiac tissues with reduced side effects by limiting the composition's migration and affecting only the intended tissues, thereby improving patient outcomes and reducing complications.
Implementation Method 1
formulated as a viscous thixotropic gel... for limiting migration of the composition and/or the ablative agent within the body after delivery to the site
Implementation Method 2
an ablative agent in accordance with the present disclosure for performing the treatment
Data Source
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AI summary
Compositions, systems, devices, and methods for performing precise chemical treatment of tissues are disclosed. Systems, devices, and methods for administering a chemical agent to one or more a precise regions within a tissue mass are disclosed. Compositions, systems, devices, and methods for treating targeted regions within a tissue mass are disclosed. Systems, devices, and methods for identifying, localizing, monitoring neural traffic in the vicinity of, quantifying neural traffic in the vicinity of, and mapping neural traffic near targeted regions within a tissue mass are disclosed.