Three-Chambered Autoinjector for Sequential Depth Delivery
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Solution Overview
Problem
Current autoinjectors lack the capability to effectively deliver multiple medicaments at different injection depths and storage-stable forms, such as lyophilized forms, which can degrade when stored in liquid form, and may violate regulatory provisions due to mixed cocktail storage restrictions.
Innovation Solution
A three-chambered autoinjector design with separate compartments for each medicament and a liquid composition, where the separation assembly allows for sequential delivery of medicaments after activation, ensuring different injection depths and immediate mixing prior to administration, thereby preventing interference and compliance with storage regulations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If multiple medicaments are stored together in a single chamber, then the device complexity is reduced, but the medicaments may degrade due to incompatible storage conditions and violate regulatory provisions
Solution Approach 1:
The device is divided into three separate chambers (first chamber for liquid composition, second chamber for lyophilized medicament, third chamber for first medicament) to enable independent storage conditions for each medicament type, preventing degradation while maintaining overall device functionality
2Quantity of substance
If medicaments are mixed and stored together, then the quantity of substance is optimized, but the mixing may cause degradation of sensitive medicaments and regulatory compliance issues
Solution Approach 1:
The liquid composition is prepared in advance in the first chamber, and the lyophilized medicament is pre-loaded in the second chamber in its stable dry form. The mixing action is delayed until the moment of injection, allowing both medicaments to be delivered efficiently while maintaining their stability during storage
3Device complexity
If a single medicament is delivered at one injection depth, then the device complexity is reduced, but the capability to deliver multiple medicaments at different depths is limited
Solution Approach 1:
The device is designed to deliver different medicaments to different locations: the first medicament is delivered at a first injection depth while the second medicament is delivered at a second injection depth, allowing each medicament to reach its optimal target tissue for maximum effectiveness
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The autoinjector ensures efficient delivery of medicaments at different depths, maintaining the stability of lyophilized forms and compliance with regulatory storage provisions, ensuring effective administration and minimizing degradation.
Implementation Method 1
the third chamber comprises a gas such as air, so that after activation of the power assembly, the gas in the third chamber can be compressed and allow the separation plunger to move forwardly within the housing
Implementation Method 2
the second medicament is in a solid form, which can be dissolved in the liquid composition
Data Source
AI summary
The present invention relates to a three-chambered autoinjector as well as to the methods of administering medicaments to a human using the three-chambered autoinjector. In certain embodiments, the autoinjector includes a first medicament in liquid form, a second medicament preferably in solid form, and a liquid composition for diluting the second medicament, and utilizes a three-chambered design so as to administer the first medicament and a solution comprising the second medicament and the liquid composition at different injection depths into the body of a human. In an alternative embodiment an autoinjector is provided that delivers medicaments at the same injection depth.