Three-Strain Lactobacillus Composition for Aging-Related Muscle Disorders
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Solution Overview
Problem
Current inventions do not utilize mixed strains of Lactobacillus for the prevention and treatment of aging-related disorders, particularly muscle-related disorders and obesity, despite the importance of intestinal microflora in health and the increasing prevalence of these issues with aging.
Innovation Solution
A composition comprising a mixture of Lactobacillus fermentum GB102, Lactobacillus fermentum GB103, and Lactobacillus plantarum GB104 strains, or their lysates and culture solutions, is used to address these issues by improving muscle strength and intestinal flora balance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If single strain Lactobacillus is used for preventing or treating muscle diseases, then the treatment effect is limited, but using mixed strains increases composition complexity
Solution Approach 1:
The patent combines multiple Lactobacillus strains (L. fermentum GB102, L. fermentum GB103, and L. plantarum GB104) into a single composition to achieve synergistic effects. This merging of multiple strains addresses the limitation of single-strain treatments while providing enhanced therapeutic effects for muscle diseases and aging-related conditions.
Solution Approach 2:
The invention creates a composite microbial preparation by formulating specific ratios of different Lactobacillus strains together with functional ingredients. This composite approach leverages the unique properties of each strain to achieve superior treatment outcomes compared to individual strains alone.
2Reliability
If mixed strains are used to improve treatment efficacy, then the therapeutic effect increases, but the manufacturing process becomes more complex
Solution Approach 1:
The patent performs preliminary selection and characterization of specific Lactobacillus strains (GB102, GB103, GB104) with proven efficacy for muscle diseases and aging conditions. By pre-identifying and optimizing these strains beforehand, the manufacturing process is simplified as the strain combinations and ratios are predetermined based on research data.
Solution Approach 2:
The invention optimizes specific parameters including strain ratios, cultivation conditions, and formulation compositions to achieve the desired therapeutic effect. By establishing standardized parameters for the mixed-strain composition, the manufacturing process becomes more controllable and scalable despite using multiple strains.
3Reliability
If multiple Lactobacillus strains are combined, then the effectiveness against aging-related disorders improves, but the cost of composition increases
Solution Approach 1:
The patent optimizes the concentration and ratio of each Lactobacillus strain in the composition to achieve the minimum effective dosage. By carefully adjusting these parameters based on in vitro and in vivo studies, the formulation maintains high effectiveness while minimizing the quantity of expensive microbial components required.
Solution Approach 2:
The selected Lactobacillus strains are chosen for their multiple beneficial functions including muscle protection, anti-aging effects, and immune modulation. This multi-functionality allows a single composition to address multiple health concerns simultaneously, providing cost-effectiveness by treating several conditions with one formulation rather than requiring separate treatments.
Data Source
AI summary
Provided are a mixture of three species of Lactobacillus fermentum strain and Lactobacillus plantarum strain and use thereof. A composition according to one aspect including, as an active ingredient, a mixture of Lactobacillus fermentum strains GB102 and GB103 and Lactobacillus plantarum strain GB104; or a lysate or culture solution thereof, or an extract of the culture solution, can be usefully used for the prevention or treatment of muscle-related disorders or obesity by alleviating the decrease in grip strength induced by aging or reducing the change in intestinal microbial environment induced by aging.