Thrombin Serum Preparation System Using Activator Beads
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Solution Overview
Problem
Current methods for preparing thrombin serum are limited in their ability to efficiently produce a clotted product from autologous blood fluids, particularly in surgical settings where controlled bleeding and tissue repair are necessary.
Innovation Solution
A system comprising a containment device with an activator, such as beads, that initiates the coagulation cascade when autologous blood fluid is added, allowing for the production of thrombin serum, which can then be used to create a clot in platelet-rich plasma or other autologous blood fluids.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If current methods for preparing thrombin serum are used, then the process can be performed with simple equipment, but the efficiency of producing clotted product is insufficient
Solution Approach 1:
The system is divided into distinct functional components: a containment device for holding blood fluid, an activator component (beads or spheres) to initiate coagulation, an inlet port for blood introduction, and an outlet port for thrombin serum removal. This segmentation allows each component to perform its specific function efficiently while maintaining overall system manageability.
Solution Approach 2:
An activator consisting of beads or spheres is introduced as an intermediary substance to trigger the coagulation cascade. These activators serve as a mediator between the blood fluid and the thrombin serum production process, enabling controlled and efficient clot formation without requiring complex external activation systems.
2Reliability
If artificial activation of coagulation cascade is implemented, then thrombin serum production is enhanced, but the system requires multiple components increasing complexity
Solution Approach 1:
The activator (beads or spheres) is pre-prepared and placed within the containment device before blood fluid introduction. This preliminary preparation ensures that when blood is added, the coagulation cascade is immediately and reliably activated, providing consistent and controlled thrombin serum production without requiring complex real-time activation systems.
Solution Approach 2:
The system utilizes the blood fluid's own coagulation factors and the activator's surface properties to automatically initiate and proceed with the coagulation cascade. Once activated, the process self-propagates through the blood fluid, converting fibrinogen to fibrin and producing thrombin serum without requiring additional external intervention or complex control mechanisms.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively produces a thrombin serum that can be used to create a clotted product for surgical applications, such as controlling bleeding and augmenting tissue repair, by artificially starting the coagulation cascade within the containment device.
Implementation Method 1
an activator (e.g., a plurality of beads or spheres) to artificially start the coagulation cascade after adding an autologous blood fluid to the containment device
Implementation Method 2
The activator can be any substance that can trigger the coagulation cascade, including glass beads, silica beads, metal beads, or other particulate matter
Implementation Method 3
Thrombin is an enzyme in blood plasma that clots blood by converting fibrinogen to fibrin
Implementation Method 4
Thrombin has many surgical uses and can be used to treat wounds or control bleeding during surgical procedures
Data Source
AI summary
A system for preparing a thrombin serum that can include a containment device, a cage received within the containment device, a cap attachable to the containment device, an inlet port configured to introduce a non-anti-coagulated autologous blood fluid into the containment device, and an outlet port. An activator, such as glass beads, can be present within the containment device.