Automated Thromboelastometry Cartridge for Multi-Assay Coagulation Testing
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Solution Overview
Problem
Existing blood testing systems for coagulation analysis require manual intervention and additional preparation steps, which are time-consuming and prone to errors, especially in point-of-care settings like surgical theaters.
Innovation Solution
An automated thromboelastometry system with a reusable analyzer console and single-use cartridges that perform multiple assays on a blood sample without manual pipetting or mixing, providing detailed and prompt results through automated transport and testing operations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If manual pipetting and mixing operations are used in blood testing systems, then reagent dispensing and sample processing can be performed, but the process becomes time-consuming and prone to errors
Solution Approach 1:
The cartridge contains an integrated pump mechanism that automatically draws blood sample and reagents through the testing chambers without requiring manual pipetting. The system performs self-service by using the pump to deliver precise volumes of blood and reagents to the appropriate chambers, eliminating manual intervention while maintaining accuracy
Solution Approach 2:
The cartridge is pre-loaded with reagents and configured with fluid pathways that are prepared in advance. The pump mechanism and fluid delivery systems are pre-positioned within the cartridge, allowing the testing process to begin immediately upon insertion into the analyzer without requiring manual preparation or setup
2Adaptability or versatility
If multiple assays are performed manually, then comprehensive blood characteristics can be analyzed, but the time required for testing increases
Solution Approach 1:
Multiple testing chambers are integrated into a single cartridge device, each capable of performing different assays simultaneously. The cartridge merges multiple fluid pathways and pump mechanisms into one unified structure, allowing parallel processing of multiple blood samples or multiple assays on a single sample without requiring separate manual operations for each test
Solution Approach 2:
The cartridge is designed as a universal platform that can perform multiple types of coagulation assays using the same basic structure. The pump mechanism and fluid delivery system serve multiple functions by routing blood and reagents to different chambers for different tests, making the cartridge multi-functional and time-efficient
3Reliability
If automated pump mechanism is used in the cartridge, then manual pipetting errors are reduced, but the device complexity increases
Solution Approach 1:
The cartridge is segmented into distinct functional modules: separate testing chambers for different assays, dedicated fluid pathways for each chamber, and individual pump mechanisms that can be independently controlled. This segmentation allows the complex automated system to be broken down into manageable, modular components that are easier to manufacture and quality-control
Data Source
AI summary
Some embodiments of a blood coagulation testing system include an analyzer console device and a single-use cartridge component configured to releasably install into the console device. In some embodiments, the blood coagulation testing system can operate as an automated thromboelastometry system that is particularly useful, for example, at a point-of-care site.