Thrombus Coring and Mesh Capture for Large-Volume DVT Removal

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Solution Overview

Problem

Current devices and methods for treating deep vein thrombosis (DVT) face challenges such as high incidence of re-occurrence, inability to handle large clot volumes, and complex treatments involving multiple devices and pharmaceuticals, which increase health risks and healthcare costs.

Innovation Solution

A thrombus extraction device comprising a self-expanding coring portion connected to a braided net is used to core and separate large volumes of thrombus from vessels, capturing it in the braided net, thereby reducing the need for pharmaceuticals and minimizing bleeding risks and recovery time.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If current devices and methods are used for treating DVT, then treatment can be performed with existing technology, but the incidence of DVT re-occurrence is high and large clot volumes cannot be effectively removed

Engineering Contradiction:

ImproveDVT treatment effectivenessVSAvoidclot removal efficiency

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The device segments the clot removal function into two distinct components: a coring portion for mechanical removal of large clot volumes and a distal filter portion for capturing fragmented thrombus. This segmentation allows simultaneous achievement of high productivity through mechanical coring and high reliability through comprehensive clot capture, preventing both large and small clot fragments from causing re-occurrence

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The device merges mechanical thrombectomy (coring) and filter thrombectomy into a single integrated system. The coring portion mechanically removes large clot volumes while the distal filter captures smaller fragments, combining the advantages of both approaches to achieve both high clot removal efficiency and high treatment reliability

Inventive Principle:

Principle #5Merging (Combining)

2Reliability

If multiple treatment devices and pharmaceuticals are used, then comprehensive treatment can be achieved, but the treatment complexity increases and health risks increase

Engineering Contradiction:

Improvetreatment comprehensivenessVSAvoidnumber of treatment devices

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The device is designed as a universal thrombectomy system that can handle various clot sizes and types within a single device. The coring portion addresses large clot volumes while the distal filter captures smaller fragments, making the device versatile enough to replace multiple specialized devices and reduce reliance on pharmaceutical interventions

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

Inventive Principle:

Principle #5Merging (Combining)

3Reliability

If thrombolytics are used extensively, then clot dissolution can be achieved, but bleeding risks and healthcare costs increase

Engineering Contradiction:

Improveclot dissolution effectivenessVSAvoidbleeding risk

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The device replaces chemical thrombolysis with mechanical thrombectomy. The coring portion mechanically removes clots through physical extraction rather than chemical dissolution, eliminating the bleeding risks associated with thrombolytic drugs while maintaining effective clot removal. The distal filter ensures complete clot capture, providing reliability without pharmaceutical side effects

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device effectively removes large clots with reduced reliance on thrombolytics, decreasing health care costs and recovery time while minimizing bleeding risks.

Implementation Method 1

a proximal self-expanding coring portion

Methodology Applied

Scientific EffectSelf-expanding: Elasticity

Implementation Method 2

a distal expandable cylindrical portion formed of a braided filament mesh structure configured to capture the vascular thrombus portion

Methodology Applied

Scientific EffectMechanical capture: Mechanical Force

Data Source

PatentEP4233744B1Device for intravascular treatment of vascular occlusion

Publication Date: 2026.01.21 STRYKER CORP

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AI summary

Systems for removal of thrombus from a blood vessel in a body of a patient are disclosed. The system can include: a thrombus extraction device including a proximal selfexpanding coring element; a distal expandable element formed of a mesh structure having a proximal end portion attached to a distal end portion of the coring element; a catheter defining a lumen configured to constrain the thrombus extraction device; an intermediate shaft coupled to a proximal end portion of the coring element; an inner shaft coupled to a distal end portion of the expandable element and slidably displaceable relative to the intermediate shaft to control expansion of the expandable element; and an introducer sheath assembly including an elongate sheath defining an insertion lumen; an expandable funnel coupled to a distal end portion of the elongate sheath; and an elongate obturator including a capture feature configured to retain the funnel in a constrained configuration. In addition, an introducer sheath assembly is also disclosed herein.