Antimicrobial Composition Using Thymol and Cationic Phospholipid

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Solution Overview

Problem

Existing antimicrobial compositions for leave-on applications lack prolonged antimicrobial efficacy while using minimal amounts of known antimicrobial ingredients.

Innovation Solution

A composition comprising 0.01 to 2% by weight of thymol, 0.01 to 2% by weight of terpineol, and 0.1 to 2% by weight of a cationic phospholipid complex, which provides prolonged antimicrobial activity against common disease-causing microbes without compromising sensorial aspects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of stationary object

If minimal amounts of known antimicrobial ingredients (thymol and terpineol) are used in leave-on formulations, then the composition remains on the skin providing prolonged antimicrobial activity, but the antimicrobial efficacy is insufficient without higher concentrations

Engineering Contradiction:

Improveprolonged antimicrobial activityVSAvoidamount of antimicrobial ingredients

Core Design Contradiction:

Duration of action of stationary objectVSQuantity of substance

Solution Approach 1:

The patent combines thymol, terpineol, and cationic phospholipid complex in a composite formulation where the cationic phospholipid complex acts as a delivery vehicle or adjuvant that enhances the antimicrobial efficacy of the minimal amounts of thymol and terpineol, allowing prolonged activity without requiring high concentrations of the antimicrobial actives

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent changes the physical or chemical parameters of the antimicrobial system by introducing cationic phospholipid complex, which may alter the delivery mechanism, stability, or bioavailability of thymol and terpineol, enabling prolonged antimicrobial activity at minimal concentrations

Inventive Principle:

Principle #35Parameter changes

2Reliability

If higher concentrations of thymol and terpineol are used to achieve sufficient antimicrobial efficacy, then the antimicrobial activity is enhanced, but the sensorial aspects of the composition are compromised

Engineering Contradiction:

Improveantimicrobial efficacyVSAvoidsensorial aspects

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The cationic phospholipid complex serves as an intermediary substance that enables the use of minimal amounts of thymol and terpineol to achieve sufficient antimicrobial efficacy, thereby avoiding the sensorial compromise that would result from using higher concentrations of these antimicrobial agents

Inventive Principle:

Principle #24Intermediary (Mediator)

3Duration of action of stationary object

If existing antimicrobial compositions are used for leave-on applications, then they provide some antimicrobial benefit, but they lack prolonged antimicrobial efficacy

Engineering Contradiction:

Improveprolonged antimicrobial efficacyVSAvoidantimicrobial efficacy

Core Design Contradiction:

Duration of action of stationary objectVSReliability

Solution Approach 1:

The patent creates a composite formulation combining thymol, terpineol, and cationic phospholipid complex that provides both prolonged duration and reliable antimicrobial efficacy, overcoming the limitation of existing leave-on compositions that lack prolonged efficacy

Inventive Principle:

Principle #40Composite materials

Data Source

PatentUS10653597B2Antimicrobial composition comprising thymol, terpineol and a cationic phospholipid

Publication Date: 2020.05.19 CONOPCO INC

AI summary

The present invention relates to an antimicrobial composition and more particularly an antimicrobial composition for leave-on applications. The present invention discloses an antimicrobial composition comprising; a) 0.01 to 2% by weight of thymol; b) 0.01 to 2% by weight of terpineol; and c) 0.1 to 2% by weight of a cationic phospholipid complex.