Thymol Ester Skin Protection Composition for DNA Damage Repair

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Solution Overview

Problem

Existing skin protection technologies are insufficient in preventing and inhibiting skin damage without side effects, particularly due to ultraviolet rays and oxidative stress, as they fail to enhance the biological ability to repair DNA damage effectively.

Innovation Solution

A composition containing 3,4,5-trimethoxycinnamate thymol ester or its stereoisomers, pharmaceutically acceptable salts, hydrates, or solvates is used as an active ingredient to increase the expression of DNA repair-related genes in skin cells, thereby enhancing their ability to repair DNA damage.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional skin protection methods are used, then skin damage from UV rays and pollutants can be partially prevented, but the ability to repair DNA damage is not effectively enhanced and may cause side effects

Engineering Contradiction:

Improveskin damage prevention effectivenessVSAvoidDNA damage repair ability

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical parameter by using 3,4,5-trimethoxycinnamate thymol ester with specific molecular structure and properties. This compound demonstrates unique ability to enhance DNA repair gene expression while providing skin protection, resolving the contradiction between prevention effectiveness and repair capability enhancement

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite protective effect by combining the 3,4,5-trimethoxycinnamate thymol ester compound with skin care composition formulations. This composite approach simultaneously achieves skin damage prevention and DNA repair enhancement without harmful side effects

Inventive Principle:

Principle #40Composite materials

2Reliability

If skin protection technology is developed to prevent skin damage, then protection effectiveness improves, but side effects occur and DNA repair ability is not sufficiently enhanced

Engineering Contradiction:

Improveprotection effectivenessVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent employs 3,4,5-trimethoxycinnamate thymol ester as a safe, effective active ingredient that works at appropriate concentrations without causing side effects. The compound provides temporary but effective protection and DNA repair enhancement, eliminating harmful long-term effects associated with conventional protection methods

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent converts the challenge of enhancing DNA repair ability into a benefit by using 3,4,5-trimethoxycinnamate thymol ester that specifically upregulates DNA repair genes. This approach transforms the previously unmet need for DNA repair enhancement into a positive therapeutic effect without introducing side effects

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Data Source

PatentUS20250213448A1Composition for protecting skin containing a thymol ester-based compound

Publication Date: 2025.07.03 AMOREPACIFIC CORP

AI summary

A composition for protecting skin, including 3,4,5-trimethoxycinnamate thymol ester, a stereoisomer, pharmaceutically acceptable salt, hydrate, or solvate thereof as an active ingredient, is disclosed. The composition can inhibit or prevent skin damage due to ultraviolet rays, external environment, or oxidative stress by increasing the expression of a DNA repair-related gene in skin cells photoaged by ultraviolet rays.