Thymoquinone Vitamin D Composition Metabolic Syndrome

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Solution Overview

Problem

There is a need for compositions of natural origin that can effectively prevent or normalize disturbances in body weight, blood glucose, and lipid levels, while also supporting the immune system and reducing inflammatory processes, particularly in the context of metabolic syndrome.

Innovation Solution

A composition comprising a combination of thymoquinone (TQ) and vitamin D, with specific ratios to achieve synergistic interactions, is used to prevent or treat changes associated with metabolic syndrome, such as insulin resistance and increased visceral fat, while supporting healthy weight management and immune function.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If pharmacological agents are used to treat metabolic syndrome, then disease parameters are controlled, but side effects increase and patient compliance decreases

Engineering Contradiction:

Improvedisease parameter controlVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical composition parameters by using natural substances (thymoquinone and vitamin D) instead of synthetic pharmacological agents. This parameter change maintains therapeutic effectiveness while eliminating harmful side effects associated with conventional drugs.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs naturally occurring substances that can be replenished through diet and supplementation, replacing long-term pharmacological interventions. These natural substances provide therapeutic benefits without accumulating harmful effects in the body.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

2Object-affected harmful factors

If nutraceutical compositions are used to prevent metabolic syndrome, then natural treatment is provided, but ability to normalize lipid and glucose parameters is insufficient

Engineering Contradiction:

Improvenatural treatmentVSAvoidnormalization of lipid and glucose parameters

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent combines two natural substances (thymoquinone and vitamin D) into a single composition, creating a synergistic effect that enhances the normalization of lipid and glucose parameters beyond what either substance could achieve alone.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent creates a composite nutraceutical composition integrating thymoquinone and vitamin D, where the combined effect of these two natural substances produces superior therapeutic outcomes for metabolic syndrome parameters compared to individual substances.

Inventive Principle:

Principle #40Composite materials

3Reliability

If thymoquinone and vitamin D are combined in specific ratios, then synergistic enhancement of biological activities is achieved, but composition complexity increases

Engineering Contradiction:

Improvesynergistic biological activityVSAvoidcomposition ratio control

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent optimizes the concentration parameters of thymoquinone and vitamin D to achieve synergistic effects. By establishing specific ratio ranges, the patent transforms a complex composition design problem into a manageable parameter optimization task.

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS20250049816A1Compositions comprising thymoquinone and vitamin d

Publication Date: 2025.02.13 N S OILS LTD

AI summary

The present invention provides a composition comprising thymoquinone (TQ) and vitamin D, wherein the weight ratio of said TQ to said vitamin D is in the range of 1:0.0001-1:1. Preferably, the composition also comprises free fatty acids, at a total concentration of 3% w/w or less. The invention is also directed to dosage forms comprising the aforementioned composition, and to various methods of treatment involving the administration of said composition and dosage forms.