Time-segmented basal rate adaptation for glucose control
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Solution Overview
Problem
Current glucose level control systems for ambulatory medical devices struggle to adapt medicament doses in real-time to changing physiological needs, leading to fluctuations in glucose levels and potential hypoglycemic or hyperglycemic events.
Innovation Solution
A glucose level control system that includes a medicament delivery interface, memory, and a hardware processor to adapt basal doses based on user input, predicted glucose levels, and measured glucose levels, using algorithms to adjust doses according to specific criteria such as food intake, exercise, and temporary illnesses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a closed loop control system is used to control medicament supply based on sensor readings, then the ability to respond to changing physiological needs is improved, but the complexity of the system increases
Solution Approach 1:
The patent segments the day into multiple time periods with different basal rates, allowing the system to adapt to changing physiological needs without requiring a completely complex real-time control system. Each time period can be independently configured with specific basal rates, simplifying the overall control logic while maintaining adaptability.
Solution Approach 2:
The system dynamically adjusts basal rates based on time of day and physiological state, transitioning between different predefined rate profiles. This dynamic adaptation allows the system to respond to changing needs while using a manageable set of pre-programmed responses rather than requiring complex real-time calculations.
2Measurement precision
If basal doses are adjusted frequently to maintain glucose levels, then glucose control precision is improved, but the risk of hypoglycemic events increases
Solution Approach 1:
The patent applies different basal rates to different time periods based on when hypoglycemia is most likely to occur. Lower basal rates are programmed for nighttime and early morning hours when the risk of hypoglycemia is highest, while higher rates are used during daytime hours when food intake and activity can prevent low blood sugar. This localized adjustment of dose quality in different temporal regions maintains precision while minimizing harmful effects.
3Adaptability or versatility
If multiple time periods with different basal rates are configured, then the adaptability to physiological changes is improved, but the device complexity increases
Solution Approach 1:
The system uses periodic action by dividing the day into standard time periods (e.g., overnight, morning, daytime, evening) with characteristic basal rates. This periodic structure provides a simple framework that automatically adapts to daily physiological rhythms without requiring complex individual customization, reducing device complexity while maintaining adaptability.
Data Source
AI summary
A glucose level control system may be configured to adapt a time-segmented basal dose. The glucose level control system may determine the first basal dose based at least in part on a user-specified basal dose and/or total daily dose value. The first basal dose may also be based on a basal dose received from the memory of the glucose level control system or from a remote storage device. The first basal dose may be administered during a first time period. The glucose level control system may adapt the first basal dose to a second basal dose for a second therapy period. The glucose level control system may adapt the second basal dose based on a difference between a predicted and measured glucose level.