Tin Oral Care Composition With Dual Ligands for Bioavailable Stability

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Solution Overview

Problem

Formulating oral care compositions with tin ions is challenging due to reactivity issues with other components, leading to under-stabilization or over-stabilization, which reduces the availability of bioavailable tin ions for desired oral care benefits.

Innovation Solution

The use of specific molar ratios of tin to monodentate and polydentate ligands, such as carboxylic acid and polyphosphate, stabilizes tin ions, ensuring optimal bioavailability and reactivity, thereby enhancing fluoride uptake and solubility reduction in oral care compositions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If tin is under-stabilized in oral care compositions, then tin can react with other components (such as silica, water), but this leads to lower availability of tin ions and hyper-reactivity with oral surfaces

Engineering Contradiction:

Improvetin stabilityVSAvoidavailable tin ions

Core Design Contradiction:

Stability of the object's compositionVSQuantity of substance

Solution Approach 1:

The patent applies parameter changes by optimizing the molar ratio of chelant to tin within specific ranges (0.5:1 to 5:1, preferably 1:1 to 3:1) and controlling pH levels (6.0-7.5) to achieve the desired balance between tin stability and bioavailability. This resolves the contradiction by finding the optimal parameter window where tin is sufficiently stabilized to prevent unwanted reactions but remains bioavailable for oral care benefits

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses composite chelating systems combining multiple chelating agents (such as citrate, gluconate, phosphate, and fluoride) working together with tin. This composite approach allows the system to provide both stabilization and controlled release of tin ions, resolving the contradiction between stability and availability through synergistic interactions among the chelating components

Inventive Principle:

Principle #40Composite materials

2Stability of the object's composition

If tin is over-stabilized or chelant-tin interaction is too strong, then tin ions are tied up when delivered to the oral cavity, but this also leads to lower amount of bioavailable tin ions

Engineering Contradiction:

Improvetin stabilityVSAvoidbioavailability of tin ions

Core Design Contradiction:

Stability of the object's compositionVSReliability

Solution Approach 1:

The patent employs partial chelation by using chelant-to-tin molar ratios that provide sufficient but not excessive stabilization. The optimized ratios (0.5:1 to 5:1, preferably 1:1 to 3:1) ensure partial chelation that stabilizes tin during storage while leaving enough unchelated or weakly chelated tin ions bioavailable for oral care benefits, resolving the contradiction between stability and reliability

Inventive Principle:

Principle #16Partial or excessive action

Solution Approach 2:

The patent creates a dynamic equilibrium system where chelant-tin complexes can reversibly dissociate to release tin ions. The chelating system maintains a dynamic balance between stabilized complexes and free tin ions, allowing the system to adapt between storage conditions (requiring stability) and oral delivery conditions (requiring bioavailability), thus resolving the contradiction through dynamic behavior

Inventive Principle:

Principle #15Dynamics

3Stability of the object's composition

If tin reacts with other components of oral care composition, then stability is affected, but this leads to lower amount of available tin ions and potential staining

Engineering Contradiction:

Improvecomposition stabilityVSAvoidstaining and reduced efficacy

Core Design Contradiction:

Stability of the object's compositionVSObject-generated harmful factors

Solution Approach 1:

The patent introduces chelating agents (citrate, gluconate, phosphate, fluoride) as intermediary substances that mediate between tin ions and other composition components. These intermediaries preferentially bind to tin ions, preventing unwanted reactions with silica, water, or other ingredients that would cause staining or reduce efficacy, while still allowing controlled release of tin for beneficial oral care effects

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The optimized ligand ratios provide unexpectedly high soluble tin amounts and fluoride uptake, maintaining effective oral care benefits throughout the composition's shelf life without interfering with other ingredients.

Implementation Method 1

the use of specific molar ratios of tin to monodentate and polydentate ligands, such as carboxylic acid and polyphosphate, stabilizes tin ions

Methodology Applied

Scientific EffectChelation:

Implementation Method 2

thereby enhancing fluoride uptake and solubility reduction in oral care compositions

Methodology Applied

Scientific EffectIon uptake:

Data Source

PatentUS20260000588A1Oral Care Compositions Comprising Monodentate And Polydentate Ligand

Publication Date: 2026.01.01 PROCTER & GAMBLE CO

AI summary

Oral care compositions including tin, monodentate ligand, and polydentate ligand with an optimized molar ratio of tin to monodentate ligand to polydentate ligand. Oral care compositions with a tin to monodentate ligand to polydentate molar ratio of from about 1:0.5:0.5 to about 1:5:5. Oral care compositions including tin, monocarboxylic acid, and tricarboxylic acid.