Biological Tissue Adhesive Nebulizer with Partition Wall
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Solution Overview
Problem
Fibrin glue preparations used in surgery often experience clogging issues at the spray tip due to their properties, leading to incomplete mixing and non-uniform application, and existing clogging prevention methods either fail to prevent clogging effectively or complicate the installation in limited surgical spaces, while also risking tissue damage.
Innovation Solution
A biological tissue adhesive nebulizer with a partition wall separating the spray ports of the fibrinogen and thrombin solutions, combined with a small clogging prevention container filled with physiological saline attached to the spray tip, prevents coagulation and clogging by maintaining the liquids in a solution state and preventing them from coming into contact with the tissue.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the fibrinogen solvent and thrombin solvent are sprayed without a partition wall, then the mixing and adhesion effect is improved, but the spray tip clogs due to premature coagulation
Solution Approach 1:
The spray tip is segmented into multiple independent channels (first solution spray port and second solution spray port) separated by a partition wall. This allows the fibrinogen solvent and thrombin solvent to be sprayed separately without premature mixing, preventing clogging while maintaining the ability to mix at the target site for effective adhesion.
Solution Approach 2:
The partition wall acts as an intermediary structure that physically separates the two solution paths. It prevents direct contact between the fibrinogen solvent and thrombin solvent in the spray tip, eliminating the clogging problem while still allowing both solutions to reach the target site for mixing and bonding.
2Productivity
If the spray tip is designed to prevent clogging by separating solution paths, then clogging is reduced, but the mixing uniformity deteriorates
Solution Approach 1:
The mixing process is shifted from the spray tip dimension to the target site dimension. By separating the solution paths only in the spray tip and allowing convergence at the target site, the system maintains spray continuity while achieving uniform mixing through the spatial arrangement of multiple spray ports at the application location.
3Ease of operation
If the two solutions are applied using the multilayer method, then the application process is simplified, but the fibrinogen solvent flows down before fibrin gel formation reducing efficacy
Solution Approach 1:
The system enables continuous simultaneous spraying of both solutions onto the target site, maintaining the reactive state of both fibrinogen solvent and thrombin solvent at the application location. This continuous action ensures immediate gel formation upon contact with tissue, preventing solvent flow-down and maintaining high adhesion efficacy.
4Device complexity
If the spray tip structure is simplified without partition walls, then the device complexity is reduced, but tissue damage risk increases due to direct contact
Solution Approach 1:
The partition wall is implemented locally at the critical spray tip region where solution separation is most needed to prevent clogging. The wall extends only partially into the spray channel, providing separation where necessary while minimizing overall structural complexity and maintaining ease of manufacturing.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The nebulizer effectively prevents clogging and ensures reliable, uniform spraying even after interruptions, while minimizing tissue damage and maintaining the convenience of installation in surgical settings.
Implementation Method 1
a partition wall (34) is provided between a distal end (31) of the first tube (30) and a distal end (31) of the second tube (30)
Implementation Method 2
the first solution injected from the first tube (30) and the second solution injected from the second tube (30) are mixed to generate and spray a biological tissue adhesive
Implementation Method 3
the housing (21) has a center axis (20) extending from a proximal side to a distal side and a proximal portion (22) and a distal portion (25) located on a proximal side and a distal side of the center axis (20), respectively, wherein the distal portion (25) has a first through hole (29) and a second through hole (29) formed along a first axis (26) and a second axis (26), respectively, extending in parallel from the proximal side toward the distal side and communicating an inside (27) and an outside (28) of the housing (21)
Data Source
AI summary
A nebulizer capable of reliably intermittently applying a biological tissue adhesive is provided. A biological tissue adhesive nebulizer includes a first tube 30 for injecting a first solution containing a first component, and a second tube 30 for injecting a second solution containing a second component that promotes clot formation of the first component. The first solution injected from the first tube and the second solution injected from the second tube are mixed to generate and spray a biological tissue adhesive. A partition wall 34 is provided between a distal end 31 of the first tube and a distal end 31 of the second tube.