Bioresorbable Tissue-Adhesive Polymer Blend for Dura Mater Sealing

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Solution Overview

Problem

Current tissue-adhesive materials for sealing dura mater face challenges such as difficult handling during surgery, post-operative swelling, low adherence strength, and limited burst-resistance, with existing solutions like DuraSeal, Hemopatch, and TissuePatchDural failing to provide adequate sealing due to their hydrogel formation requirements and bioresorbability issues.

Innovation Solution

A bioresorbable tissue-adhesive polymer blend comprising a synthetic carrier polymer, such as poly(DL-lactide-co-ε-caprolactone), combined with a tissue-reactive polymer like multi-arm polyethylene glycol (PEG) and a buffering agent, which forms a stable covalent bond with dura mater, offering improved adhesive strength and burst-resistance without the need for mechanical application or post-operative complications.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If hydrogel-forming materials (two-component system) are used for sealing dura mater, then sealing capability is achieved, but handling difficulty increases and post-operative swelling occurs

Engineering Contradiction:

Improvesealing capabilityVSAvoidhandling difficulty

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The material is divided into two functional components: a bioresorbable polymer matrix providing structural support and sealing capability, and a tissue-adhesive polymer providing bonding strength. This segmentation allows each component to optimize its function while improving overall handling and performance.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The invention uses a composite material system combining bioresorbable polymer and tissue-adhesive polymer in a single-phase formulation. This composite approach achieves both sealing and adhesive functions without requiring separate hydrogel components, thereby improving handling while maintaining reliability.

Inventive Principle:

Principle #40Composite materials

2Reliability

If conventional sealants are used, then sealing is achieved, but adhesive strength is insufficient

Engineering Contradiction:

Improvesealing functionVSAvoidadhesive strength

Core Design Contradiction:

ReliabilityVSStrength

Solution Approach 1:

The invention merges sealing and adhesive functions into a single integrated material system. The tissue-adhesive polymer component specifically enhances adhesive strength to dura mater while the bioresorbable matrix maintains sealing function, resolving the contradiction between sealing reliability and adhesive strength.

Inventive Principle:

Principle #5Merging (Combining)

3Strength

If non-bioresorbable materials are used, then structural strength is maintained, but bioresorbability and biocompatibility are reduced

Engineering Contradiction:

Improvestructural strengthVSAvoidinflammatory response

Core Design Contradiction:

StrengthVSObject-affected harmful factors

Solution Approach 1:

The invention changes the material parameter from non-bioresorbable to bioresorbable while maintaining structural strength through the polymer matrix design. The controlled bioresorbability ensures the material provides necessary strength during the critical healing period while eventually degrading to avoid long-term inflammatory responses and foreign body reactions.

Inventive Principle:

Principle #35Parameter changes

4Reliability

If mechanical application methods are used, then secure attachment is achieved, but surgical complexity and operation time increase

Engineering Contradiction:

Improveattachment securityVSAvoidsurgical complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The tissue-adhesive polymer provides self-adhesive properties that enable the material to bond to dura mater without requiring mechanical fixation devices such as sutures, staples, or clips. This self-service capability reduces surgical complexity and operation time while maintaining secure attachment through chemical adhesion to the tissue.

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The polymer blend provides a strong, durable seal that remains effective for the duration of dura mater healing, with enhanced adhesive strength and burst-resistance, reducing the risk of cerebrospinal fluid leakage and minimizing inflammatory responses, while being easily applicable during surgery and biocompatible.

Implementation Method 1

combined with a tissue-reactive polymer like multi-arm polyethylene glycol (PEG) and a buffering agent, which forms a stable covalent bond with dura mater

Methodology Applied

Scientific EffectCovalent bonding: Chemical Bonding

Implementation Method 2

The breakdown of the materials typically occurs through hydrolysis or enzymatic cleavage into smaller compounds that may be metabolized or excreted

Methodology Applied

Scientific EffectHydrolysis: Hydrolysis

Implementation Method 3

The breakdown of the materials typically occurs through hydrolysis or enzymatic cleavage into smaller compounds that may be metabolized or excreted

Methodology Applied

Scientific EffectEnzymatic cleavage: Enzyme

Data Source

PatentUS11779679B2Tissue-adhesive material

Publication Date: 2023.10.10 POLYGANICS IP BV

AI summary

The invention is directed to a tissue-adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue-reactive polymer as well as to a tissue-adhesive device for sealing dura mater comprising said tissue-adhesive polymer blend.