Tissue Cooling System for Sterile Preservation
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Solution Overview
Problem
Current tissue removal systems fail to precisely and atraumatically excise neurological tissue without damaging the tissue or surrounding tissues, and they do not preserve the integrity of the resected tissue for use in personalized medicine protocols, as they often cause thermal or ablative damage and lack a sterile environment for transport and analysis.
Innovation Solution
A tissue cutting device with a fluid supply sleeve that delivers irrigants, hemostatic agents, and tissue sealants, combined with a cooling system to maintain tissue viability and integrity, allowing for precise cutting and preservation of tissue samples in a sterile environment, minimizing physical and environmental stress during removal and transport.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If ablative or thermal energy is used to remove tissue, then tissue removal efficiency is improved, but tissue integrity and viability are damaged
Solution Approach 1:
The patent replaces thermal and ablative energy systems with a mechanical cutting system that uses a rotating blade to physically slice through tissue. This mechanical approach allows for precise cutting without the thermal damage associated with ablation, thereby maintaining tissue integrity while achieving effective tissue removal.
Solution Approach 2:
The patent introduces a sterile collection device as an intermediary between the cutting blade and the tissue sample. This device captures the excised tissue immediately upon cutting and transports it in a controlled environment, preventing contamination and maintaining viability without requiring thermal or chemical preservation methods that could damage the tissue.
2Productivity
If traditional tissue removal devices are used, then tissue excision is achieved, but precise and atraumatic removal without damage to surrounding tissues is not achieved
Solution Approach 1:
The patent employs a focused, localized cutting mechanism where the rotating blade engages only the specific tissue target within the cannula. This localized action allows precise excision of the abnormal tissue mass while leaving surrounding healthy tissues undisturbed, as the cutting action is confined to the immediate surgical site within the cannula structure.
Solution Approach 2:
The patent divides the tissue removal process into distinct segments: the cutting blade removes only the targeted abnormal tissue, while the sterile collection device separately captures and preserves the excised sample. This segmentation allows for precise removal without compromising surrounding tissues, as each component performs its function independently and locally.
3Ease of operation
If tissue samples are collected without a sterile environment, then collection simplicity is improved, but tissue contamination and loss of biological activity occur
Solution Approach 1:
The patent merges the cutting function and collection function into a single integrated device. The sterile collection device is attached directly to the cannula, allowing the tissue sample to be cut and captured in one continuous motion without exposure to non-sterile environments. This integration maintains simplicity of operation while ensuring sterility and biological activity preservation.
Solution Approach 2:
The collection device utilizes sterile barriers and materials that create a controlled environment within the collection chamber. These sterile components form a composite structure that maintains biological activity while allowing the device to remain simple in operation, as the sterility is built into the device structure rather than requiring complex external preservation systems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system enables the collection and preservation of intact, biologically active tissue samples, maintaining their integrity for pathological evaluation and subsequent use in personalized medicine therapies, such as targeted chemotherapy and immunotherapy, by preventing thermal damage and ensuring a sterile transport environment.
Implementation Method 1
a cooling system to maintain tissue viability and integrity
Implementation Method 2
A tissue cutting device with a fluid supply sleeve that delivers irrigants, hemostatic agents, and tissue sealants
Data Source
AI summary
A cooling system for preserving tissue is disclosed. The cooling system comprises a base member, a temperature control sleeve constructed of a thermally conductive material, and a selectively removable lid member. The base member defines a reservoir and receives the temperature control sleeve. The temperature control sleeve at least partially defines a tissue collector chamber that is configured to receive a tissue collector. The temperature control sleeve is in communication with the reservoir. The reservoir is configured to receive a cooling medium. A slit formed within the tissue collection chamber that is sized to receive a tubing connected to the tissue collector therethrough. The lid member is configured to be selectively attached to the base member, and permit access to a tube mount for the tissue collector when the lid is attached to the base member.