Tissue Dicing Device with Reciprocating Blades and Vortex Separation
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Solution Overview
Problem
Current methods for promoting tissue healing around fistulae, such as those caused by congenital defects, inflammatory bowel disease, or surgical procedures, lack effective solutions for accelerating regeneration and closure, particularly in challenging anatomical locations like anal fistulas.
Innovation Solution
A device and method for mincing and processing tissue to create a medical fluid composition that includes viable tissue fragments and biocompatible materials, which can be delivered to the fistula site to promote healing, using a tissue dicing and particle separation device and a fistula plug assembly system, allowing for the injection of a scaffold material impregnated with a cell matrix to facilitate tissue regeneration and closure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If tissue is harvested and processed to create biological components for healing, then tissue regeneration is promoted, but the complexity of the device and process increases
Solution Approach 1:
The patent combines multiple functions (tissue harvesting, dicing, and delivery) into a single integrated device system. The tissue harvesting device collects tissue, which is then processed by dicing blades within the same system to create particles, and finally delivered to the target site, eliminating the need for separate processing equipment and reducing overall system complexity.
Solution Approach 2:
The tissue dicing blades are nested within the housing of the tissue harvesting device. The blades are positioned inside the same chamber where tissue is collected, allowing for in-situ processing without requiring external equipment. This nested arrangement integrates multiple functions within a compact structure.
2Productivity
If tissue particles are created through dicing to promote healing, then tissue regeneration is accelerated, but the manufacturing precision requirements increase
Solution Approach 1:
The dicing blades are designed to move relative to each other in a dynamic cutting action. The blades can be positioned at different heights and angles, allowing them to progressively reduce tissue size through multiple passing cuts. This dynamic approach enables effective particle size reduction without requiring extremely precise initial positioning.
Solution Approach 2:
The dicing process utilizes periodic reciprocating motion of the blades, where the blades move back and forth through the tissue sample in repeated cycles. This periodic action gradually reduces tissue size over multiple passes, achieving adequate particle size for healing without requiring single-pass ultra-precision cutting.
3Stability of the object's composition
If a scaffold material impregnated with cell matrix is delivered to anchor tissue repair, then tissue healing is stabilized, but the device complexity increases
Solution Approach 1:
The scaffold material is pre-impregnated with the cell matrix before delivery to the target site. The tissue particles are incorporated into the scaffold structure in advance, creating a pre-assembled construct that maintains stability upon delivery. This preliminary preparation eliminates the need for complex assembly mechanisms at the delivery stage.
Solution Approach 2:
The treatment composition is formulated as a composite material combining scaffold material, cell matrix, and tissue particles into a single integrated substance. This composite approach provides structural stability while incorporating all necessary biological components, eliminating the need for separate delivery mechanisms for each component.
Data Source
AI summary
A tissue dicing and separation device comprises a housing having an interior that receives tissue for dicing and separation. The device includes a blade assembly connected to a motor and solenoid. The solenoid reciprocates the blade assembly while the motor clocks the blade assembly during each reciprocation cycle. This reciprocating and clocking action of the blade assembly dices and/or minces the tissue. The housing is filled with a fluid and then the blade assembly is continuously rotated to create a vortex within the housing. The vortex causes the diced tissue particles to separate by particle size. Outlets at different positions along the housing permit withdrawal of a slurry of fluid and tissue particles with the tissue particles having a desired size range. The obtained slurry may be used in conjunction with a fistula plug treatment device and method.