Tissue Disaggregation Bag with Clamp Assembly
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Solution Overview
Problem
Existing methods for tissue sample disaggregation struggle to process multiple samples under identical conditions, leading to inconsistencies in sample analysis.
Innovation Solution
A treading device apparatus with a sample processing bag and clamp assembly that allows for controlled disaggregation of tissue samples, enabling multiple samples to be processed under the same conditions, using a cyclic treading motion and adjustable feet to limit pressure and prevent contamination.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If multiple tissue samples are processed simultaneously under the same conditions, then processing efficiency and comparability are improved, but device complexity increases due to the need for multiple sample containers and clamps
Solution Approach 1:
The clamp assembly is designed with a universal base support structure that can accommodate multiple sample containers in a standardized manner. The clamp mechanism serves multiple functions: securing sample containers, maintaining consistent positioning, and enabling simultaneous processing of multiple samples under identical conditions, thereby improving productivity without proportionally increasing complexity
Solution Approach 2:
The device is segmented into modular components including individual sample containers, dedicated clamp assemblies for each container, and a base support structure. This segmentation allows for independent optimization of each component while maintaining overall system consistency, enabling multiple samples to be processed simultaneously with comparable results
2Reliability
If a closed system is used to maintain sterility and cell viability, then sample quality is improved, but ease of operation deteriorates due to difficulty in loading and unloading samples
Solution Approach 1:
Sample containers are pre-loaded with tissue samples and sealed before being placed into the device. The clamp assembly is pre-configured with a base support structure that facilitates easy insertion and secure positioning of containers. This preliminary preparation maintains sterility and cell viability while simplifying the loading and unloading operations during processing
3Reliability
If consistent processing conditions are applied to multiple samples, then analysis reliability is improved, but adaptability deteriorates when sample types or sizes differ
Solution Approach 1:
The clamp assembly incorporates adjustable components that allow dynamic adaptation to different sample container sizes and configurations. The base support structure can be positioned and secured at various locations, enabling the same device to maintain consistent processing conditions across different sample types while preserving analysis reliability through standardized clamping and positioning mechanisms
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Facilitates efficient and consistent disaggregation of tissue samples, maintaining cell viability and sterility, while allowing for flexible processing and storage of samples under identical conditions, reducing errors and improving analysis reliability.
Implementation Method 1
the at least one foot assembly acts on the sample processing bag to disaggregate any tissue therein
Data Source
AI summary
The present invention relates to a sample processing bag (10) for use in a tissue disaggregation apparatus (200) for disaggregation of tissue therein. A clamp assembly 60 comprising a base support (70) and a clamp mechanism (72) is configured to retain the sample processing bag (10) adjacent to the base support (70) during a tissue disaggregation operation such that action of the tissue disaggregation apparatus 200 acts on the sample processing bag (10) to disaggregate any tissue therein.