Tissue Elasticity Mapping Through Image Registration
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Solution Overview
Problem
Existing methods struggle to accurately diagnose chronic diseases like COPD in early stages due to minimal functional disturbances and subtle tissue property changes that are not well reflected in medical images.
Innovation Solution
A system and method for determining tissue-specific properties by providing and registering multiple images of a region of interest, identifying specific tissue regions, and calculating elastic registration outputs to accurately assess tissue elasticity, using techniques like Jacobian determinant maps and anisotropic deformation indices.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If multiple separate measurements are performed to determine different tissue properties (elasticity, viscosity, surface properties), then comprehensive tissue characterization is achieved, but measurement time and procedural complexity increase
Solution Approach 1:
The patent combines multiple measurement functions (elasticity, viscosity, surface properties) into a single probe system that performs all measurements simultaneously during one procedural insertion, eliminating the need for multiple separate measurements and reducing total measurement time
Solution Approach 2:
The probe is designed as a universal measurement device capable of determining multiple different tissue properties through a single integrated system, allowing one probe to perform functions that previously required multiple specialized devices
2Measurement precision
If multiple separate measurements are performed to determine different tissue properties, then comprehensive tissue characterization is achieved, but device complexity and number of components increase
Solution Approach 1:
Multiple measurement functions are merged into a single integrated probe assembly, reducing the number of separate devices and components needed while maintaining the capability to measure all required tissue properties
Solution Approach 2:
A universal probe design performs multiple measurement types through integrated sensors and processing circuitry, simplifying the overall system architecture compared to using multiple specialized devices
3Ease of operation
If conventional measurement approaches are used without tissue-specific calibration, then measurement process is simplified, but measurement accuracy for specific tissue types deteriorates
Solution Approach 1:
The system automatically adjusts measurement parameters and calibration factors based on the detected tissue type, optimizing measurement accuracy for each specific tissue while maintaining ease of operation through automated parameter selection
4Productivity
If a single measurement provides limited tissue property information, then measurement time is reduced, but diagnostic information completeness deteriorates
Solution Approach 1:
The single probe performs multiple measurement functions simultaneously, providing comprehensive tissue property information (elasticity, viscosity, surface properties) in one measurement event, thus maintaining high productivity while avoiding information loss
Data Source
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AI summary
The present invention refers to providing a system that allows to very accurately determine the state of a disease, like COPD, in a patient. The system (100) comprises a unit (101) for providing images of the region of interest corresponding to different states of the region of interest, a unit (102) for elastically registering the images to each other resulting in an elastic registration output, a unit (103) for determining a specific tissue region in an image, a unit (104) for determining a specific elastic registration output for the specific tissue region based on the determined elastic registration output, and a unit (105) for determining an elastic indicator for the specific tissue type based on the specific elastic registration output. Thus, a state of a disease that influences the elastic properties of the specific tissue type can be determined very accurately.