Tissue Fluid Extraction Using Hypertonic Solution for Glucose Monitoring
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Solution Overview
Problem
Existing methods for measuring blood glucose levels in diabetes diagnosis cannot accurately determine how long a high glucose state continues, limiting their effectiveness in assessing glucose tolerance and identifying conditions like hidden diabetes.
Innovation Solution
An in vivo component measurement method that extracts tissue fluid for 60 minutes or more using a hypertonic aqueous solution with auxiliary components like potassium chloride, glycine, or urea to enhance osmotic pressure, allowing for the measurement of glucose levels and electrolytes, and calculating the area under the blood concentration time curve to determine the duration of high glucose states.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If tissue fluid is extracted using conventional methods (without enhancement treatment), then the extraction process is simple, but the extraction efficiency is insufficient and cannot provide accurate information about prolonged high glucose states
Solution Approach 1:
The patent applies preliminary action by performing enhancement treatment (forming fine pores in the skin) before tissue fluid extraction. This pretreatment creates conditions that facilitate subsequent extraction, allowing sufficient tissue fluid to be collected within 60 minutes for accurate AUC calculation, thereby resolving the contradiction between extraction efficiency and process complexity.
Solution Approach 2:
The patent utilizes porous materials by forming fine pores in the skin through enhancement treatment. These pores increase the surface area and permeability for tissue fluid extraction, significantly improving extraction efficiency without requiring complex extraction devices or procedures.
2Measurement precision
If tissue fluid extraction time is extended to 60 minutes or more, then the total amount of measurement target component can be accurately measured, but the measurement time increases
Solution Approach 1:
By performing enhancement treatment beforehand to form fine pores in the skin, the patent enables sufficient tissue fluid extraction within 60 minutes. This preliminary action ensures that the extraction time is just long enough to obtain accurate AUC data without unnecessary delays, balancing measurement precision with time efficiency.
3Quantity of substance
If conventional extraction methods are used, then the procedure is simple, but the amount of tissue fluid extracted is insufficient for accurate AUC calculation
Solution Approach 1:
The patent forms fine pores in the skin through enhancement treatment, creating a porous structure that significantly increases tissue fluid extraction capacity. This approach obtains sufficient tissue fluid volume for accurate AUC calculation while maintaining extraction method simplicity, resolving the contradiction between quantity obtained and method complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method provides accurate and reliable measurements of glucose levels over time, enabling better assessment of glucose tolerance and identification of prolonged high glucose states, thus improving diabetes diagnosis and management.
Implementation Method 1
extracting tissue fluid to an extraction medium containing a hypertonic aqueous solution having a higher osmotic pressure than pure water
Data Source
AI summary
An in vivo component measurement method allowing how long a high concentration state of a measurement target component continues in an organism to be grasped is provided. In this in vivo component measurement method, a value relating to an amount of a measurement target component in tissue fluid extracted for 60 minutes or more from an organism on which a treatment for enhancing extraction of tissue fluid has been made is acquired.