Biological Tissue Forming Package With Magnetic Sliding Assembly
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Solution Overview
Problem
Current methods for forming cell sheets are time-and-cost-consuming, requiring specific culture centers, and are prone to contamination or damage during transportation.
Innovation Solution
A biological tissue forming method using a package with a base, membrane, sliding assembly, passive magnetic elements, and a light-transmitting sealing film, which allows for the dispensing and curing of biological tissue fluid into a tissue near the clinical site.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If cell sheets are formed in a specific culture center by culturing cells for a long time, then the cell sheets can be formed with proper structure, but the process is time-consuming and costly
Solution Approach 1:
The patent applies preliminary action by pre-preparing the cell suspension and loading it into the dispensing system before the actual tissue formation. The cell suspension is prepared in advance and stored in the dispenser, allowing for rapid deployment at the clinical site without requiring time-consuming on-site cell culture processes.
Solution Approach 2:
The patent replaces the traditional biological culture process with a physical dispensing and curing system. Instead of relying on extended cell culture in incubators, the invention uses a dispensing system that deposits cell suspension and immediately cures it through UV light irradiation, substituting the biological time-consuming process with a rapid physical-chemical process.
2Adaptability or versatility
If cell sheets are formed in a culture center and transported to medical facilities, then they can be used at clinical sites, but the transportation process poses risks of contamination or damage
Solution Approach 1:
The patent segments the cell tissue formation process into two distinct phases: (1) cell suspension preparation and loading into the dispensing system, and (2) on-site dispensing and curing at the clinical site. This segmentation eliminates the need to transport fragile, living cell sheets, as only the stable cell suspension and the robust dispensing system need to be transported, significantly reducing contamination and damage risks.
Solution Approach 2:
The dispensing system is designed to be self-contained and portable, allowing it to be transported to various clinical sites without requiring infrastructure support. The system includes its own power source, UV curing mechanism, and cell suspension storage, enabling it to perform tissue formation independently at the point of use, thereby eliminating the need for complex transportation and preservation logistics.
3Productivity
If a portable dispensing system is used to form tissue at the clinical site, then the process becomes quick and cost-effective, but the system complexity increases
Solution Approach 1:
The patent applies universality by designing the dispensing system to perform multiple functions within a single integrated device: (1) storing cell suspension, (2) dispensing the suspension through controlled deposition, (3) providing UV light irradiation for immediate curing, and (4) controlling the entire process parameters. This multi-functionality consolidates what would otherwise require separate equipment, reducing overall system complexity while maintaining high productivity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables quick and cost-effective formation of biological tissue near the clinical site, reducing the risk of contamination and damage, and providing a stable environment for immediate usage.
Implementation Method 1
The at least one passive magnetic element is configured to be magnetically attracted to move the sliding assembly
Implementation Method 2
emitting the biological tissue fluid exposed on the membrane by a curing light transmitting through the one of the base and the sealing film so as to cure the biological tissue fluid into a biological tissue
Data Source
AI summary
This disclosure relates to a biological tissue forming method includes the following steps: providing a biological tissue forming package with a base, a membrane, a sliding assembly and a sealing film that seals a chamber of the base used for receiving the membrane and the sliding assembly with one of the base and the sealing film being light-transmitting; passing a biological tissue fluid through the sealing film and the sliding assembly so as to be dispensed on the membrane; moving the sliding assembly away from a covering position used for covering the membrane via at least one passive magnetic element so as to expose the biological tissue fluid on the membrane; and emitting the biological tissue fluid exposed on the membrane by a curing light transmitting through the one of the base and the sealing film so as to cure the biological tissue fluid into a biological tissue.