Tissue Graft Retainer Segmentation for Cryopreservation Media Flow

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Solution Overview

Problem

Current packaging systems for tissue grafts fail to effectively maintain the viability of cryopreserved tissue grafts during storage and transportation, as they often cause mechanical stress and hinder the flow of cryopreservation media, leading to compromised cell viability.

Innovation Solution

A tissue graft packaging system with a retainer composed of two separate members that form a continuous interior space with minimal contact points, allowing for the flow of cryopreservation media and minimizing mechanical stress on the tissue graft, while also facilitating easy thawing and rinsing.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional packaging systems are used for tissue grafts, then the graft is contained and protected, but the packaging causes mechanical stress and hinders the flow of cryopreservation media, leading to compromised cell viability

Engineering Contradiction:

Improvecell viabilityVSAvoidmechanical stress

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The packaging system is divided into two separate members (first member and second member) that can be removed independently. This segmentation allows the first member to remain in contact with the tissue graft during cryopreservation to provide structural support, while the second member is removed to eliminate mechanical stress and allow free flow of cryopreservation media throughout the graft structure.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The second member is extracted from the packaging system after initial containment is established. This removal eliminates the harmful mechanical contact that would otherwise restrict media flow and cause stress to the tissue graft, while the first member remains to continue providing necessary structural support.

Inventive Principle:

Principle #2Taking out (Extraction)

2Reliability

If traditional packaging systems are used for tissue grafts, then the graft is contained, but the packaging hinders the flow of cryopreservation media

Engineering Contradiction:

Improvecell viabilityVSAvoidcryopreservation media flow

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

Inventive Principle:

Principle #2Taking out (Extraction)

3Device complexity

If a single-piece packaging structure is used, then the structure is simple, but it causes mechanical stress and hinders media flow

Engineering Contradiction:

Improvepackaging structureVSAvoidcell viability

Core Design Contradiction:

Device complexityVSReliability

Solution Approach 1:

Inventive Principle:

Principle #1Segmentation

4Reliability

If minimal contact packaging is used, then mechanical stress is reduced, but containment and protection may be compromised

Engineering Contradiction:

Improvecell viabilityVSAvoidcontainment protection

Core Design Contradiction:

ReliabilityVSStrength

Solution Approach 1:

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

Inventive Principle:

Principle #2Taking out (Extraction)

Data Source

PatentUS10695157B2Packaging system for tissue grafts

Publication Date: 2020.06.30 MUSCULOSKELETAL TRANSPLANT FOUND INC

AI summary

A tissue graft packaging system having a retainer including first and second members with respective first and second pluralities of channel sidewalls that define first and second pluralities of channels, and first and second engagement means configured to removeably interconnect the first and second members. The first and second pluralities of channel sidewalls are configured to create a continuous interior space between the first and second members. A tissue graft, such as a cryopreserved viable tissue graft, is contained within the continuous interior space of the retainer. Processes for packaging, thawing and rinsing the tissue graft using the tissue graft packaging system and its retainer are also disclosed.