Tissue Harvesting Tip with Integrated Maceration and Cell Sizing
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Solution Overview
Problem
Current tissue engineering procedures are time-consuming, costly, and involve multiple surgical procedures, with a need for more efficient methods and devices that maximize cell viability and provide a compact, easy-to-use solution for tissue extraction and processing.
Innovation Solution
A tissue extraction device with a hollow harvesting tip featuring cutting elements and openings, allowing for efficient excision and maceration of tissue samples, coupled with a driver mechanism for rotation and a sizing screen to control particle size, facilitating the collection of viable tissue samples for subsequent use in tissue engineering techniques.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a biopsy is performed to remove a tissue sample from a patient's body and the tissue sample is sent to a laboratory for cell isolation, then cells can be obtained for tissue engineering, but the procedure becomes time-consuming and involves multiple surgical procedures
Solution Approach 1:
The patent combines multiple functions (tissue excision, maceration, and cell separation) into a single integrated device that can be performed during one surgical procedure. The harvesting tip with cutting elements removes tissue while simultaneously macerating it through rotating blades, and the sizing screen separates cells in real-time, eliminating the need for separate laboratory processing steps and reducing overall procedural time while maintaining cell viability.
Solution Approach 2:
The harvesting tip is divided into distinct functional segments: cutting elements for tissue removal, macerating blades for tissue breakdown, and a sizing screen for cell separation. This segmentation allows each component to perform its specific function efficiently within the same device, enabling comprehensive tissue processing in a single operation rather than requiring multiple separate procedures.
2Ease of manufacture
If traditional biopsy devices are used to remove tissue samples, then tissue can be obtained, but the process requires multiple steps and is costly
Solution Approach 1:
The harvesting tip is designed as a universal multi-functional component that can excise tissue, macerate it, and separate cells through a single device. This eliminates the need for multiple specialized devices and sequential procedures, simplifying the overall treatment protocol while maintaining comprehensive tissue processing capabilities. The single device performs what previously required multiple separate instruments and procedures.
3Productivity
If a hollow harvesting tip with cutting elements and openings is used, then tissue can be excised and macerated efficiently, but the device structure becomes more complex
Solution Approach 1:
The harvesting tip employs a nested structure where macerating blades are positioned inside the hollow tip, and a sizing screen is nested within the macerating chamber. This nested arrangement allows multiple processing stages (excision, maceration, separation) to occur within a compact, integrated geometry, improving tissue processing efficiency without requiring a proportionally complex external structure. The nested design maximizes functional density within a manageable form factor.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device enables efficient removal and processing of tissue samples with high cell viability, reducing procedural time and costs while providing a compact, user-friendly solution for surgeons, enhancing the efficiency of tissue engineering processes.
Implementation Method 1
The cutting elements comprise cutting surfaces that are disposed around the circumference of the tissue harvesting tip for excise of tissue upon rotation of the tip
Implementation Method 2
the openings are formed in a wall of the tissue harvesting tip to allow excised pieces of tissue to pass into the hollow tip
Data Source
Figure 1A
Figure 1B
Figure 2A
AI summary
Methods and device for extracting and collecting tissue, which can be used for example in tissue engineering and grafting applications, are disclosed. In one embodiment, a device can include an outer tube. A rotatable shaft can be disposed within the outer tube can have a tissue harvesting tip formed on its distal end, the tissue harvesting tip being effective to excise tissue upon rotation thereof. A tissue collection device can be included to receive and collected excised tissue, and the tissue collection device can indicate the amount of tissue collected therein. For example, the tissue collection device can include a straining element which collects excised tissue and an indicator by which to assess the amount of collected tissue. In some embodiments, the tissue collection device can translate to indicate the amount of collected tissue. In many cases, devices disclosed herein can include driving mechanisms that are adapted to drive a tissue harvesting tip such that the tip excises soft tissue, but stops when contacting bone (or soon after contacting bone). In some embodiments, the tissue harvesting tip can be effective to excise viable tissue samples, such that the samples can exhibit desirable proportions of viable cells. Further, in some embodiments, the tissue harvesting tips can excise a tissue sample with tissue particles falling in certain size ranges.