Biological Tissue Image Analysis via Geometric Contour Fitting

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Solution Overview

Problem

Current biopsy examination methods rely on subjective interpretation by professionals, leading to varying assessment accuracy and lack of quantitative analysis of tissue morphology, limiting the objective assessment and advancement of related technologies.

Innovation Solution

A method and system for analyzing biological tissue images that involves image pre-processing, contour fitting using edge-finding methods, and calculating regional averaged object sizes and angles to provide quantitative morphological features, enabling precise and objective analysis of tissue morphology.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If professionals perform subjective interpretation of tissue images, then assessment can be conducted, but assessment accuracy varies and consistency is poor

Engineering Contradiction:
Improveassessment consistencyVSAvoidassessment accuracy
Core Design Contradiction:
ReliabilityVSMeasurement precision

Solution Approach 1:

The patent replaces the manual mechanical interpretation process with an automated image analysis system using edge-finding algorithms and geometric shape fitting. The system automatically identifies contours, fits geometric shapes to target objects, and calculates quantitative parameters, eliminating subjective human interpretation and providing consistent, precise measurements across all tissue images.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The system enables self-service analysis where the tissue images are automatically processed without requiring professional interpretation. The automated algorithm performs edge detection, contour identification, geometric fitting, and parameter calculation independently, providing reliable and consistent results without human intervention.

Inventive Principle:
Principle #25Self-service

2Productivity

If qualitative description of tissue morphology is used, then analysis can be performed quickly, but objective assessment is limited and technological advancement is hindered

Engineering Contradiction:
Improveanalysis speedVSAvoidquantification accuracy
Core Design Contradiction:
ProductivityVSMeasurement precision

Solution Approach 1:

The patent transforms qualitative morphological descriptions into quantitative parameters by calculating geometric properties such as area, perimeter, circularity, and aspect ratio of fitted shapes. This parameter transformation enables precise objective assessment while maintaining efficient automated processing, resolving the contradiction between analysis speed and quantification accuracy.

Inventive Principle:
Principle #35Parameter changes

3Measurement precision

If automated image analysis system is developed, then quantitative analysis with high accuracy can be achieved, but system complexity increases

Engineering Contradiction:
Improvequantitative analysis accuracyVSAvoidsystem complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent segments the image analysis process into distinct modular steps: edge detection, contour identification, geometric shape fitting, and parameter calculation. Each module performs a specific function independently, making the overall system more manageable and easier to implement despite the complexity of achieving high-precision quantitative analysis.

Inventive Principle:
Principle #1Segmentation

Data Source

PatentUS11551358B2Method for analyzing biological-tissue image and system for analyzing biological-tissue image
Publication Date: 2023.01.10 CHINA MEDICAL UNIVERSITY(TW)
  • US11551358B2 patent drawing
  • US11551358B2 patent drawing
  • US11551358B2 patent drawing

AI summary

A method for analyzing biological-tissue image includes following steps. A plurality of biological-tissue images are provided, and each of the biological-tissue images includes a plurality of target object image blocks. An image pre-processing step is performed so as to obtain a plurality of processed biological-tissue images. A fitting step is performed so as to obtain a plurality of object fitting images of the target object image blocks. A sampling step is performed, wherein a target region of each of the processed biological-tissue images is selected, and the target region includes the object fitting images. A calculating and analyzing step is performed so as to obtain an analysis result of a target regional center of the biological-tissue images.