Tissue Insertion Member Cooling for Adipose Apoptosis

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Solution Overview

Problem

Current methods for separating or eradicating adipose tissue in plastic surgical procedures often risk damaging blood vessels, nerves, skin, or other structures, and lack effective means for regenerating ischemic or injured tissue.

Innovation Solution

A tissue separation and equalization device with a cannula and expandable tissue separating members that separate adipose tissue without damaging surrounding structures, and an optional cold fluid source to induce apoptosis for tissue eradication, along with a mechanism to stimulate regeneration by inducing an 'adipose injury cocktail' response in adipose-derived stromal cells.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If mechanical separation methods are used to separate adipose tissue, then tissue separation is achieved, but risk of damage to blood vessels, nerves, skin or other structures increases

Engineering Contradiction:

Improvetissue separation safetyVSAvoiddamage to surrounding structures

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces mechanical separation methods with a chemical/biological approach using deoxycholic acid injection. The substance induces adipocyte destruction through a biochemical mechanism rather than physical disruption, thereby eliminating the risk of mechanical damage to surrounding structures while achieving effective fat separation and removal

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

Deoxycholic acid serves as an intermediary substance that mediates the separation and removal of adipose tissue. It acts as a biochemical agent that selectively targets adipocytes, causing them to undergo lysis and release their contents, thus achieving tissue separation without direct mechanical intervention that could harm surrounding structures

Inventive Principle:

Principle #24Intermediary (Mediator)

2Quantity of substance

If traditional fat eradication methods are used, then adipose tissue removal is achieved, but damage to surrounding structures occurs

Engineering Contradiction:

Improveadipose tissue removalVSAvoiddamage to blood vessels, nerves, skin

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent applies local quality by injecting deoxycholic acid directly into the target adipose tissue in a localized manner. The substance acts selectively on adipocytes in the injection area, causing their destruction and removal, while the surrounding structures remain unaffected due to the localized application and selective biochemical action on fat cells

Inventive Principle:

Principle #3Local quality

3Productivity

If aggressive tissue separation methods are used, then separation efficiency is improved, but tissue injury increases

Engineering Contradiction:

Improvetissue separation efficiencyVSAvoidtissue injury

Core Design Contradiction:

ProductivityVSObject-generated harmful factors

Solution Approach 1:

The patent replaces aggressive mechanical separation methods with a biochemical process. Deoxycholic acid injection induces controlled adipocyte lysis and inflammation that naturally leads to fat removal and tissue separation over time, achieving efficient separation without the immediate tissue injury caused by aggressive mechanical methods

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device efficiently separates adipose tissue with reduced risk of damage to surrounding structures, enables effective eradication of adipose tissue, and promotes tissue regeneration by stimulating an 'adipose injury cocktail' response, significantly expediting procedures and improving outcomes.

Implementation Method 1

reducing a temperature of the tissue insertion member

Methodology Applied

Scientific EffectThermal conduction: Conduction (thermal)

Data Source

PatentUS11819256B1Methods of inducing apoptosis in tissues

Publication Date: 2023.11.21 WALL JR SIMEON

AI summary

Methods of inducing apoptosis in a tissue may include providing a tissue separation and equalization device having a generally elongated tissue insertion member, providing an incision in tissue, inserting the tissue insertion member of the tissue separation and equalization device through the incision into the tissue reducing a temperature of the tissue insertion member and removing the tissue insertion member from the tissue.