Tissue Micro-Cutting Device for Preserving 3D Biomatrix Structure
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Solution Overview
Problem
Conventional methods for treating chronic and acute tissue injuries and degeneration fail to preserve the three-dimensional tissue super-structures and biomatrix, often requiring enzymatic digestion, which loses supportive substances and factors, and are not suitable for low-cost or simultaneous treatments.
Innovation Solution
A device and method for preparing a suspension of polyhedron-shaped tissue micro-transplants using non-destructive precision-cutting, preserving the 3D tissue super-structures and biomatrix, which can be applied by injection, dripping, or spraying.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If enzymatic digestion is used to prepare single cell solutions, then individual cells can be isolated, but the biomatrix structure and supportive substances are lost
Solution Approach 1:
The patent replaces enzymatic digestion (chemical method) with mechanical micro-cutting using a precision blade device. The blade physically sectionstissue into micro-transplants that retain the biomatrix structure, eliminating the need for enzymes like trypsin or collagenase that would otherwise digest and lose the supportive substances.
Solution Approach 2:
The tissue is segmented into micro-transplant units of controlled size (e.g., 0.1-2mm diameter) through mechanical cutting. This segmentation approach allows the tissue to be divided into transplantable units while preserving the intact biomatrix and cell-niche structures within each micro-transplant, rather than completely dissociating into single cells.
2Manufacturing precision
If multi-step enzymatic treatment is used to obtain cell solutions, then single cells are isolated, but the process becomes complex and lengthy
Solution Approach 1:
The invention extracts and eliminates the need for multiple enzymatic treatment steps and washing procedures by using direct mechanical micro-cutting. The single-step mechanical sectioning process produces ready-to-use micro-transplant suspensions without requiring sequential enzyme applications, incubation periods, or extensive washing to remove enzymatic residues.
Solution Approach 2:
The mechanical micro-cutting device performs the complete tissue preparation function in one operation, where the rotating blade automatically sections tissue into micro-transplants that are immediately suitable for transplantation. The process is self-contained and does not require additional processing steps or external interventions.
3Reliability
If conventional surgery is used for tissue repair, then treatment can be provided, but it is not suitable for chronic and acute tissue injuries and age-related degeneration
Solution Approach 1:
The mechanical micro-cutting device provides a universal preparation method that can process various tissue types (skin, cartilage, bone, muscle, organ tissue) into micro-transplants suitable for different clinical applications. This single technology platform replaces the need for tissue-specific preparation methods and can address both acute injuries and chronic degenerative conditions across multiple tissue types.
4Ease of manufacture
If manual cutting of tissue into small pieces is used, then tissue can be transplanted, but the 3D tissue super-structures are not preserved
Solution Approach 1:
The patent replaces manual cutting with a controlled mechanical micro-cutting system using a rotating blade. This mechanical system precisely sections tissue into uniform micro-transplants while preserving the internal 3D tissue super-structures and cell-niche organizations within each micro-transplant, achieving both ease of preparation and structural preservation simultaneously.
Data Source
AI summary
The present invention relates to a tissue polyhedron suspension, wherein said tissue fragments are obtainable by cutting donor tissue using a defined device. Furthermore, the invention discloses a device for preparing the suspension and various methods of using the suspension for treating condition by injecting the suspension into tissue, dripping, or pipetting, or squirting, or spraying the suspension onto tissue. The present invention relates to a device and method for tissue-structure isolation and a resulting suspension of polyhedron-shaped tissue fragments, exhibiting the three-dimensional (3D) tissue super-structures of the original structures. These tissue fragments are tissue micro-transplants such as polyhedron-shaped tissue micro-transplants, obtainable by non-destructive medical precision-cutting donor tissue using the described device. Furthermore, the invention discloses a device for preparing the suspension and various methods of using the suspension for treating condition by injecting the suspension into tissue, dripping, or pipetting, or squirting, or spraying the suspension onto tissue in need of repair or regeneration.