Tissue Oxygenation Mapping with Temperature-Compensated Phosphorescence
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current endoscopic technologies miss approximately 25% of polyps during screenings, despite enhanced endoscopy, and there is a lack of clinically practical methods for quantitatively assessing tissue oxygenation to improve polyp detection.
Innovation Solution
A multi-modality imaging system utilizing oxygen-dependent phosphorescence and temperature sensing to generate accurate tissue oxygenation maps, compensating for temperature-dependent variations, and integrating these maps with endoscopic video for precise lesion identification.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional endoscopy is used for polyp detection, then the procedure is simple and widely available, but approximately 25% of polyps are missed during screenings
Solution Approach 1:
The patent combines multiple imaging modalities (white light endoscopy, narrow band imaging, and oxygenation mapping) into a single integrated system. This allows simultaneous acquisition of anatomical and functional information, improving polyp detection accuracy without requiring separate procedures or devices.
Solution Approach 2:
The system uses false color mapping to represent tissue oxygenation levels, where different colors indicate different oxygenation states. This visual enhancement allows clinicians to quickly identify areas of abnormal oxygenation that may indicate polyps or other pathology, improving detection accuracy.
2Measurement precision
If temperature compensation is implemented in phosphorescence lifetime measurements, then oxygenation measurement accuracy is improved, but device complexity and calibration requirements increase
Solution Approach 1:
The system incorporates temperature sensing that provides real-time feedback to the oxygenation measurement process. The measured temperature is used to compensate for thermal effects on phosphorescence lifetime, creating a closed-loop system that maintains measurement accuracy across varying temperature conditions.
Solution Approach 2:
Temperature acts as an intermediary parameter that mediates between the physical measurement environment and the oxygenation calculation. By measuring temperature and using it as a correction factor, the system indirectly accounts for thermal effects on phosphorescence without directly measuring oxygen concentration under varying thermal conditions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances the detection of pre-cancerous polyps by providing quantitative tissue oxygenation maps, improving the accuracy of lesion identification and guiding interventions.
Implementation Method 1
tissue oxygenation is assessed utilizing the technique of oxygen dependent quenching of phosphorescence
Implementation Method 2
a temperature sensor for detecting the temperature at one or more points in the field of view of the optical sensor
Data Source
AI summary
Apparatus, systems, and methods are provided that generate in vivo maps of oxygenation measurements of biological tissue. These may include surgical instruments and stand-alone imaging systems with incorporated oxygen sensing capability. Oxygenation maps can be determined via fluorescent or phosphorescent lifetime imaging of an injectable probe with an oxygen-dependent optical response. Probe configuration and methods and apparatus of injecting the probe into the tissue are provided. Methods and apparatus for temperature compensation of temperature-dependent lifetime measurements are provided to improve oxygenation measurement accuracy. Oxygen maps may be registered with visible light images to assist in assessing tissue viability or localize anomalies in the tissue. Resulting oxygen images may be used for various applications including, but not limited to, guiding surgical procedures such as colorectal resection through use of intraoperative sensing, enhanced endoscopic imaging for identifying suspect lesions during colonoscopy, and external imaging of tissue such as assessing peripheral vascular disease.