Biological Tissue Packaging with Flexible Membrane
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Solution Overview
Problem
Developing an appropriate transport system for autologous cell therapies that maintains the integrity and viability of cells during transport, while minimizing physical and biological degradation, is challenging due to the need for careful handling and specialized packaging that prevents tension, fluid movement, bubble formation, and exposure to non-toxic materials.
Innovation Solution
A biological tissue packaging and transport system comprising a series of sterilized aseptic containers, including a clamshell container, a pouch, a secondary package, and a tertiary package, designed to minimize movement, maintain fluid circulation, prevent bubble formation, and ensure non-toxic materials, while allowing for sterilization and ease of use.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the tissue product is placed in a packaging system that allows fluid circulation, then the tissue product receives constant fluid feeding, but fluid movement may cause a rubbing effect that damages the tissue product
Solution Approach 1:
The patent employs a flexible membrane that selectively permeates to culture medium, allowing fluid to pass through while providing a barrier that prevents direct contact between the tissue product and bulk fluid movement. This resolves the contradiction by enabling nutrient supply through the membrane while isolating the tissue from harmful rubbing effects of fluid circulation.
Solution Approach 2:
The flexible membrane acts as an intermediary between the fluid circulation system and the tissue product. It mediates the transfer of culture medium nutrients to the tissue while blocking the transmission of mechanical stress and rubbing effects, thus allowing fluid feeding without causing damage.
2Stability of the object's composition
If the packaging system uses a rigid structure to prevent tissue deformation, then the tissue product is protected from floating and curling, but the packaging system becomes more complex and difficult to sterilize
Solution Approach 1:
The patent uses a flexible membrane that conforms to the tissue product shape, providing support and preventing deformation through gentle containment rather than rigid structures. This achieves shape stability while maintaining packaging simplicity and sterilizability, as the flexible membrane can be autoclaved and adapts to the tissue without requiring complex rigid frameworks.
3Manufacturing precision
If the packaging system is designed to perfectly fit the biological product, then the tissue product is securely held, but the packaging system loses adaptability for different tissue products with varying features
Solution Approach 1:
The flexible membrane packaging system naturally conforms to the specific shape and size of different tissue products through its elasticity and pliability. This allows the same packaging design to adapt to various tissue features (clips, sutures, shapes) while maintaining secure fit, thus achieving both precision and versatility without requiring custom-designed packages for each tissue type.
Data Source
AI summary
Embodiments of the present disclosure are directed to a biological tissue packaging system, as well as a transport system, and, in some embodiments, comprises a first package, a secondary package, and a tertiary package. Each of the first, second, and tertiary packages is sterilized prior to packaging of a biological tissue therein. The first package comprises a pouch, and a first tray and a first lid configured for removable snap-fit attachment to one another so as to form a clamshell container. The secondary package is configured to contain the first package and interlock therewith. The tertiary package is configured to contain the secondary package and interlock therewith.