Formaldehyde-Free Tissue Preservation Composition for Histology
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Solution Overview
Problem
Existing formaldehyde-based compositions used for preservation and fixation in histological and body preservation techniques pose health risks due to their harmful effects on human and animal health, necessitating the development of safer and more ecological alternatives.
Innovation Solution
A composition comprising propolis, Origanum vulgare extract, Thymus vulgaris extract, alcohol, and a penetrating agent, which fixes and preserves biological samples without altering their appearance or structure, offering a formaldehyde-free alternative for histological analysis and body preservation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If formaldehyde-based compositions are used for preservation and fixation, then preservation effectiveness is improved, but health safety deteriorates due to carcinogenic, neurotoxic, and irritant properties
Solution Approach 1:
The invention changes the chemical composition parameters by replacing formaldehyde with a combination of propolis, Origanum vulgare extract, Thymus vulgaris extract, alcohol, and penetrating agents. This substitution maintains preservation effectiveness while eliminating the harmful toxic properties of formaldehyde, thus resolving the contradiction between reliability and health safety
Solution Approach 2:
The invention uses a composite preservative composition combining multiple natural extracts (propolis, Origanum vulgare, Thymus vulgaris) with alcohol and penetrating agents. This composite approach achieves the preservation effectiveness previously provided by formaldehyde while avoiding its toxic effects, thereby resolving the technical contradiction
2Duration of action of stationary object
If formaldehyde-based compositions are used for body preservation, then preservation duration is improved, but ecological safety deteriorates
Solution Approach 1:
The invention modifies the compositional parameters by substituting synthetic formaldehyde with natural extracts and bio-based components. This change maintains adequate preservation duration while improving ecological safety by eliminating persistent environmental contaminants and toxic byproducts associated with formaldehyde decomposition
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively preserves biological samples and bodies, maintaining structural integrity and appearance, while avoiding the toxicity associated with formaldehyde, suitable for histological analysis and thanatopraxy care.
Implementation Method 1
a penetrating agent, with a content of at least 20% (by weight relative to the total weight of the composition
Implementation Method 2
a penetrating agent, with a content of at least 20% (by weight relative to the total weight of the composition
Implementation Method 3
a propolis, the content of which is less than 1% (by dry weight of propolis relative to the total weight of the composition) an extract Origanum vulgare, containing an extract of which is less than or equal to 1% (by weight relative to the total weight of the composition) Thymus vulgaris
Data Source
AI summary
The present invention relates to a composition comprising propolis, an extract of Origanum vulgare, an extract of Thymus vulgaris, an alcohol and a penetrating agent, which proves to be particularly useful for the preservation of tissues and organs, especially with regard to biological samples intended for analysis by a histological technique.