Tissue Processing System Using Two Reaction Modules
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Solution Overview
Problem
Current tissue processing methods require multiple solutions and complex systems, leading to increased costs, space requirements, and complexity, which hinders efficient healthcare delivery and tissue analysis.
Innovation Solution
A simplified tissue processing system using only two different chemical solutions in two separate reaction modules, one for heating and one for vacuum processing, with optional conveyance to transfer specimens between modules, reducing the number of chemical compositions and mechanical/electrical components.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If multiple solutions and complex systems are used for tissue processing, then processing completeness and specimen quality are improved, but equipment size, costs, and system complexity increase
Solution Approach 1:
The patent combines multiple tissue processing functions (dehydration, clearing, impregnation) into a single integrated solution system. Instead of using separate reaction chambers for each processing step, the invention uses one reaction chamber that accommodates multiple solutions sequentially, thereby reducing the number of mechanical and electrical components while maintaining complete tissue processing capability
Solution Approach 2:
The single reaction chamber is designed to serve multiple functions by accommodating different solutions for different processing steps. The chamber can hold dehydrating agent, clearing agent, and impregnating agent sequentially, making it a universal vessel that replaces multiple specialized chambers, thus simplifying the overall system architecture
2Reliability
If multiple solutions and reaction modules are used, then tissue processing completeness is improved, but equipment size and space requirements increase
Solution Approach 1:
The patent merges multiple reaction modules into a single integrated system. By combining the functions of multiple reaction chambers into one chamber that can accommodate multiple solutions, the physical footprint of the equipment is reduced while maintaining the capability to perform complete tissue processing through sequential solution application
3Reliability
If multiple chemical compositions are used, then processing effectiveness is improved, but stockpiling costs and operational expenditures increase
Solution Approach 1:
The single reaction chamber is designed to be universal and accommodate multiple different chemical solutions for different processing steps. This multi-functional design allows the system to achieve complete tissue processing effectiveness while using a consolidated chemical delivery system, reducing the need for multiple separate chemical storage and delivery systems
4Productivity
If more reaction modules are used, then tissue processing capability is improved, but equipment costs and operational expenses increase
Solution Approach 1:
The patent combines multiple reaction modules into one integrated reaction chamber system. By merging the functionality of multiple expensive modules into a single chamber that can handle multiple solutions, the equipment costs are reduced while maintaining full tissue processing capability through the sequential application of different solutions in the same chamber
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach decreases processing time, improves specimen quality, and reduces equipment size and costs, enabling more efficient and affordable tissue processing, particularly in resource-constrained settings, while maintaining effective histological examination and genetic analysis capabilities.
Implementation Method 1
one first module in which the reaction contents are at least heated
Implementation Method 2
one second module in which the reaction contents are at least under vacuum
Data Source
AI summary
Improved systems and methods for tissue processing are described here. The chemical process and the construction of the apparatus are simplified by using only two different solutions in two separate reaction modules. They are compatible with processing of tissue specimens for genetic analysis, histology, in situ antibody binding and hybridization, archival preservation of morphology and nucleic acids, and combinations thereof.