Tissue Retrieval Device with Platens for Amnion Integrity
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Solution Overview
Problem
The retrieval and preservation of amnion and chorion tissues from afterbirth are complicated by their thin, tensile, and notch-sensitive nature, which can lead to tearing and curling, compromising cellular viability and requiring careful handling to maintain integrity for future clinical use.
Innovation Solution
A device with a working platform to secure and separate the membranes into flat, stable samples, using platens and diskette assemblies to prevent curling and facilitate cryogenic storage, while allowing for the creation of multiple sub-samples and immersion in a transport liquid for preservation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional handling methods are used for amnion and chorion tissues, then the tissues can be retrieved, but they are prone to tearing and curling due to their thin and notch-sensitive nature
Solution Approach 1:
The patent introduces a retrieval device with a support surface and securing mechanism that acts as an intermediary between the operator and the fragile tissue. The device includes a base with a support surface and a securing member that can hold the tissue in a flat, stable state during handling, preventing tearing and curling while facilitating easy manipulation.
2Reliability
If the tissues are handled carefully to maintain integrity, then cellular viability is preserved, but the retrieval and storage process becomes more complex and time-consuming
Solution Approach 1:
The patent combines multiple functions into a single integrated retrieval device. The device integrates the support surface, securing mechanism, and storage preparation features into one unit, allowing the user to perform retrieval, stabilization, and preparation for cryogenic storage without switching between multiple tools or complex procedures.
Solution Approach 2:
The device is designed to maintain tissue integrity automatically once placed on the support surface. The securing member and flat surface work together to prevent curling and tearing without requiring continuous manual intervention, reducing the time and complexity of the retrieval process while preserving cellular viability.
3Duration of action of stationary object
If the tissues are stored in a flat, stable state for cryogenic preservation, then long-term storage efficacy is improved, but the handling and positioning requirements increase
Solution Approach 1:
The device prepares the tissue for long-term storage by maintaining it in a flat, stable state on the support surface before cryogenic preservation. The securing member is positioned to hold the tissue flat in advance, ensuring optimal conditions for long-term storage without requiring complex positioning adjustments during the storage process.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device ensures the integrity and viability of amnion and chorion tissue samples by maintaining them in a flat, stable state during handling and storage, enabling efficient retrieval, separation, and preservation for future medical applications.
Implementation Method 1
A device with a working platform to secure and separate the membranes into flat, stable samples, using platens and diskette assemblies to prevent curling
Implementation Method 2
facilitate cryogenic storage
Data Source
AI summary
A device is provided for securing a tissue sample from biological material. The tissue sample is housed in bottom and top platens that are configured to promote fluid communication between the tissue sample and the exterior environment to permit transport or cryogenic fluid to contact the sample. Additionally, diskette assemblies may be provided within the platens that permit sub-samples to be separated without directly handling the tissue sample. The diskette assemblies may also be configured to promote fluid communication with the sub-sample housed therein.