Tissue Sample Container With Segmented Orientation

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Current methods for transporting and processing tissue samples are prone to misidentification, cross-contamination, and damage due to manual handling, which can lead to loss of sample orientation and increased processing time, especially when multiple samples from different sites are handled together.

Innovation Solution

A tissue sample container with individually configured sections to maintain the orientation and identity of each sample, featuring a base with sample holding sections and a lid that securely seals the samples, allowing for automated processing and fixation while preventing sample rotation, and incorporating a fluid dispensing mechanism for fixative distribution without opening the container.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If multiple tissue samples are placed in the same container for transport, then transport efficiency is improved, but sample identification and orientation are lost

Engineering Contradiction:
Improvetransport efficiencyVSAvoidsample identification and orientation
Core Design Contradiction:
ProductivityVSLoss of information

Solution Approach 1:

The container is divided into multiple individually configured sample holding sections, each capable of maintaining the orientation and identity of a specific tissue sample. This segmentation allows multiple samples to be transported together while preserving their individual characteristics through dedicated compartments with unique geometries that prevent rotation and maintain spatial orientation.

Inventive Principle:
Principle #1Segmentation

2Ease of operation

If tissue samples are handled manually during processing, then flexibility in processing is improved, but misidentification and cross-contamination increase

Engineering Contradiction:
Improveprocessing flexibilityVSAvoidsample identification accuracy
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

The container maintains sample orientation and identity throughout transport and processing by incorporating fixed geometric configurations in each sample holding section. This preliminary establishment of proper sample positioning eliminates the need for manual re-orientation during processing, reducing handling steps and minimizing opportunities for misidentification and cross-contamination while maintaining processing flexibility.

Inventive Principle:
Principle #10Preliminary action

3Reliability

If the container is opened during fixation to add fixative, then fixation effectiveness is improved, but sample exposure to contamination is increased

Engineering Contradiction:
Improvefixation effectivenessVSAvoidcontamination risk
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The container incorporates a sealed fixation mechanism where fixative can be introduced through a closed system. The fixative is delivered via a sealed port or automated injection system that maintains the closed-state of the container, allowing effective fixation to occur while eliminating the need to open the container and thereby preventing contamination exposure.

Inventive Principle:
Principle #24Intermediary (Mediator)

4Object-affected harmful factors

If samples are transported in a closed container, then contamination is prevented, but sample orientation may be lost

Engineering Contradiction:
Improvecontamination preventionVSAvoidsample orientation
Core Design Contradiction:
Object-affected harmful factorsVSStability of the object's composition

Solution Approach 1:

The closed container is segmented into multiple sample holding sections, each with a unique geometric configuration designed to maintain the specific orientation of its contained tissue sample. The closed-state of the container prevents contamination while the individualized sections with fixed geometries preserve sample orientation throughout transport, resolving the contradiction between sealed protection and orientation maintenance.

Inventive Principle:
Principle #1Segmentation

Data Source

PatentUS10092905B2Tissue sample container and methods
Publication Date: 2018.10.09 LEICA BIOSYSTEMS NUSSLOCH GMBH
  • US10092905B2 patent drawing
  • US10092905B2 patent drawing
  • US10092905B2 patent drawing

AI summary

A tissue sample container including a base having a plurality of sample holding sections, which are configured to receive a plurality of tissue samples in a given orientation and are demarcated by section walls; and a lid configured to sealingly engage the base. The sample holding sections are sized and shaped to correspond to a specific tissue sample size and shape such that the base in cooperation with the section walls, maintain the given orientation and identity of the tissue samples within respective sample holding sections.