Biological Tissue Sampling Device with Integrated Optical Localization
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Solution Overview
Problem
Sampling biological tissues, especially in inaccessible areas like brain tumors, is challenging due to the complexity of accurate localization without external imaging systems like MRI, and existing minimally invasive devices face difficulties in precise targeting.
Innovation Solution
A minimally invasive device with a nanoporous or micro-structured capture surface and an integrated optical system, including an observation window and a bundle of optical fibers, allows for accurate localization and sampling without MRI, using an optical return system and a guide tube for precise positioning.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If MRI is used for localization, then measurement precision is improved, but device complexity and availability worsen
Solution Approach 1:
The patent extracts the localization function from the complex MRI imaging system and implements it directly in the sampling device through an integrated optical system with observation window and optical fibers, eliminating the need for external MRI equipment while maintaining localization capability
Solution Approach 2:
The patent introduces an optical system as an intermediary between the sampling device and the practitioner's visual system, allowing direct observation of the target tissue through the observation window and optical fibers without requiring MRI imaging
2Ease of operation
If direct visual observation is implemented, then ease of operation is improved, but device complexity worsens
Solution Approach 1:
The patent nests the optical fibers and observation window within the sampling device structure, with the optical system integrated into the rod housing, allowing direct visual observation without adding significant external complexity to the overall device
Solution Approach 2:
The patent combines multiple functions into the optical system - the observation window serves both as a structural component of the device housing and as the optical interface for visualization, while the optical fibers provide both illumination and imaging capabilities
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate and minimally invasive sampling of biological tissues by providing real-time visual feedback for precise targeting, reducing the risk of tissue damage and eliminating the need for external imaging systems.
Implementation Method 1
a housing extending in the rod, parallel to the longitudinal axis, from the proximal end as far as the observation window, said housing being able to receive a bundle of optical fibers
Implementation Method 2
an optical return system adapted for producing optical coupling between the distal end of the bundle and the observation window. According to an embodiment, the optical return system comprises a reflective plate orientated by an angle comprised between 40 and 50° relatively to the longitudinal axis of the rod
Data Source
AI summary
The invention relates to a device (100) for sampling a biological tissue comprising:a rod (1) extending along a longitudinal axis (X) between a proximal end (1a) and a distal end (1b),a capture surface (2) borne by the rod (1), intended to be applied against a biological tissue, wherein the capture surface is nanoporous or has protrusions adapted for sampling a biological tissue by micro abrasion,an observation window (3) transparent to visible light, laid out in the external surface of the rod (1),a housing (4) extending in the rod, parallel to the longitudinal axis, from the proximal end (1a) as far as the observation window (3) said housing being able to receive a bundle of optical fibers.