Tissue Sampling Device Single Puncture Trajectory Optimization
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Solution Overview
Problem
Conventional tumor biopsy techniques limit the areas that can be sampled, leading to sampling errors and an incomplete representation of the tumor's genetic composition, especially in heterogeneous tumors, due to a single puncture approach which may not accurately reflect the primary genetic makeup of the tumor.
Innovation Solution
A system utilizing a tissue sampling device with multiple degrees of freedom, guided by image-based segmentation and optimization algorithms, allows for the acquisition of tissue samples from multiple locations within a tumor using a single skin puncture, enabling more comprehensive sampling by determining optimal trajectories and entry points based on three-dimensional imaging.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a single puncture approach is used to minimize bleeding risk, then safety is improved, but sampling completeness deteriorates
Solution Approach 1:
The patent divides the tumor into multiple sub-volumes based on image-based segmentation, identifying multiple sampling locations within the tumor that can be accessed through a single puncture trajectory. This segmentation allows comprehensive sampling of heterogeneous tumor regions while maintaining the safety benefit of a single skin puncture.
Solution Approach 2:
The patent employs a sampling device with multiple degrees of freedom that can move along multiple trajectories within the tumor after a single puncture. By adding dimensional movement capabilities (multiple trajectories, entry points, and sampling locations), the system achieves comprehensive sampling without requiring multiple skin punctures.
2Quantity of substance
If multiple punctures are used to sample different tumor areas, then sampling completeness is improved, but safety deteriorates
Solution Approach 1:
The sampling device is designed with multiple degrees of freedom, allowing it to dynamically change trajectories and sampling locations after a single puncture. This dynamic capability enables the device to access multiple tumor regions without requiring multiple static punctures, thereby maintaining safety while improving sampling completeness.
3Ease of operation
If a single trajectory is used to simplify the procedure, then ease of operation is improved, but measurement precision deteriorates
Solution Approach 1:
The system segments the tumor into multiple sub-volumes and identifies multiple sampling locations within a single trajectory framework. This segmentation approach maintains procedural simplicity by using one puncture while ensuring accurate tumor representation by sampling from multiple segmented regions.
Solution Approach 2:
The system uses image-based feedback to identify optimal sampling locations and trajectories. By incorporating imaging guidance and optimization algorithms, the system automatically determines the best sampling strategy, maintaining ease of operation while achieving high measurement precision through accurate tumor characterization.
Data Source
AI summary
A system includes acquisition of a three-dimensional image based on at least two two-dimensional images, identification of a tumor based on the three-dimensional image, identification of sub-volumes of the tumor, determination of a first two or more tissue sampling locations based on the sub-volumes, determination of a first tissue sampling device entry point and a first one or more device trajectories associated with the first entry point based on the first tissue sampling locations, movement of a tissue sampling device into the patient volume through patient skin at the first entry point, and movement of the device along the first one or more device trajectories to acquire tissue samples from the first tissue sampling locations, wherein the tissue samples are acquired from the first tissue sampling locations between entry of the device at the first entry point and removal of the device from the first entry point.