Porous Tissue Scaffold With Enclosed Pocket For Viable Cell Retention
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Solution Overview
Problem
Current tissue repair techniques are time-consuming, costly, and require multiple surgical procedures, with limitations in availability and potential for disease transmission, necessitating a more efficient and reliable method for tissue regeneration.
Innovation Solution
A composite implant featuring a porous tissue scaffold with a pocket to retain viable tissue, optionally with bioactive substances to stimulate cell growth, which can be quickly prepared and used during surgery, promoting integration with native tissue.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current tissue engineering techniques are used to repair tissue, then tissue regeneration can be achieved, but the process becomes time-consuming and requires multiple surgical procedures
Solution Approach 1:
The patent applies preliminary action by pre-seeding viable cells onto the scaffold structure before implantation. This eliminates the need for separate cell isolation and culture steps that would require multiple surgical procedures, as the scaffold arrives at the surgical site already prepared with functional cells ready for immediate integration
Solution Approach 2:
The patent merges multiple functions into a single implant device by combining the scaffold structure, viable cells, and delivery mechanism into one integrated unit. This consolidation eliminates the need for separate procedures for tissue harvesting, cell culture, and implantation, thereby reducing overall treatment time
2Reliability
If manual cell isolation and culture techniques are used, then viable cells can be obtained for tissue regeneration, but the process becomes labor-intensive and costly
Solution Approach 1:
The patent applies self-service by utilizing the patient's own viable cells that are already present in the target tissue, eliminating the need for external cell culture facilities and labor-intensive manipulation. The cells are harvested directly from the injury site and immediately incorporated into the scaffold, making the process self-contained and reducing external resource requirements
Solution Approach 2:
The patent extracts only the essential viable cells directly from the injured tissue without requiring full tissue harvesting and extensive processing. This selective extraction of functional cells from the injury site eliminates the need for complex cell isolation protocols and reduces manufacturing complexity
3Quantity of substance
If allografts are used for tissue repair, then graft material is available, but there is limited availability and potential for disease transmission
Solution Approach 1:
The patent converts the previously harmful aspect of using patient's own tissue (which required traumatic harvesting) into a benefit by using the viable cells already present at the injury site. This approach eliminates disease transmission risks associated with allografts while utilizing the patient's own biological material, transforming a potential harm into a therapeutic advantage
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composite implant facilitates efficient tissue regeneration and integration, reducing the need for multiple surgeries and improving the reliability of tissue repair with a cost-effective solution.
Implementation Method 1
a porous tissue scaffold having at least one pocket formed therein
Implementation Method 2
The top and bottom portions can be at least partially mated to one another, and in an exemplary embodiment they are heat sealed to one another around a perimeter thereof to form an enclosed pocket therebetween
Data Source
AI summary
A composite implant is provided for repairing a tissue defect in a patient. In one embodiment, the implant is a porous tissue scaffold having at least one pocket formed therein and adapted to contain a viable tissue. The tissue scaffold can have a variety of configurations, and in one embodiment it includes top and bottom portions that can be at least partially mated to one another, and in an exemplary embodiment that are heated sealed to one another around a perimeter thereof to form an enclosed pocket therebetween. The pocket is preferably sealed with a viable tissue disposed therein. In another embodiment, the tissue scaffold is substantially wedge-shaped and the pocket comprises a hollow interior formed in the tissue scaffold, and/or at least one lumen extending into the tissue scaffold. The tissue scaffold can also optionally include at least one surface feature formed thereof to promote blood vessel formation.