Tissue Scaffold Polymer-ATM Composite Structure

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Solution Overview

Problem

Current devices for treating tissue or organ defects lack stability and induce significant immunological or inflammatory responses when implanted, limiting their effectiveness in tissue regeneration.

Innovation Solution

A tissue scaffold is created by dissolving a polymer in a solvent, mixing it with a particulate acellular tissue matrix, and molding it into a stable three-dimensional shape, where the matrix is encased in the polymer to reduce immunological and inflammatory responses upon implantation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If a polymer is used to create a stable three-dimensional structure for tissue regeneration, then structural stability is improved, but immunological or inflammatory response increases

Engineering Contradiction:

Improvestructural stabilityVSAvoidimmunological or inflammatory response

Core Design Contradiction:

Stability of the object's compositionVSObject-affected harmful factors

Solution Approach 1:

The patent combines polymer material with acellular tissue matrix (ATM) to create a composite scaffold. The ATM component reduces immunogenicity while the polymer provides structural stability, resolving the contradiction between structural integrity and biocompatibility.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The acellular tissue matrix acts as an intermediary between the polymer scaffold and the host immune system. It mediates the interaction by reducing the immunogenic response while allowing the polymer to fulfill its structural function.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Object-affected harmful factors

If acellular tissue matrix is used alone for tissue regeneration, then biocompatibility is improved, but structural stability deteriorates

Engineering Contradiction:

Improveimmunological or inflammatory responseVSAvoidstructural stability

Core Design Contradiction:

Object-affected harmful factorsVSStability of the object's composition

Solution Approach 1:

The patent creates a composite where ATM is encased in polymer, combining the biocompatibility of ATM with the structural stability of polymer to achieve both benefits simultaneously.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The acellular tissue matrix is encased within the polymer structure, creating a nested configuration where the inner ATM provides biocompatibility and the outer polymer provides structural support.

Inventive Principle:

Principle #7Nested doll (Nesting)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The scaffold provides a stable three-dimensional structure for tissue regeneration with reduced immunological and inflammatory responses, promoting effective tissue repair and regeneration with improved biocompatibility.

Implementation Method 1

drying the mixture to form a tissue scaffold

Methodology Applied

Scientific EffectEvaporation: Evaporation

Implementation Method 2

dissolving a polymer in a solvent to make a solution

Methodology Applied

Scientific EffectSolvation: Solvation

Data Source

PatentEP3351273B1Preparation of regenerative tissue scaffolds

Publication Date: 2020.05.20 LIFECELL CORP

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AI summary

Devices and methods for treating or repairing a tissue or organ defect or injury are provided. The devices can include tissue scaffolds produced from a cellular tissue matrices and polymers, which have a stable three-dimensional shape and elicit a limited immunologic or inflammatory response.