Tissugenic Implants with ECM Matrix for Tissue Integration

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Solution Overview

Problem

Current surgical implants that incorporate cells, growth factors, and a physical matrix lack effective methods for integrating and stabilizing these components within the body's tissue compartments, leading to suboptimal integration and functionality.

Innovation Solution

Development of surgical implants that utilize a combination of cells, growth factors, and a physical matrix, specifically designed to interact with the extracellular matrix (ECM) components such as glycosaminoglycans, proteoglycans, and collagen, to enhance tissue integration and regeneration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If surgical implants use a physical matrix structure, then tissue integration is improved, but component stability and integration effectiveness deteriorate

Engineering Contradiction:

Improvetissue integrationVSAvoidcomponent stability

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The implant uses a composite structure combining a physical matrix (such as collagen or other ECM components) with integrated cell populations and growth factors. This composite approach allows the implant to simultaneously provide structural support for tissue integration while maintaining component stability through the synergistic interaction of multiple elements within the matrix framework.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The physical matrix serves as an intermediary carrier that mediates between the cells/growth factors and the host tissue environment. The matrix provides a scaffold that facilitates tissue integration while its structural properties maintain the stability and controlled release of integrated components, resolving the contradiction between integration and stability.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Productivity

If surgical implants incorporate cells and growth factors, then tissue regeneration is improved, but integration effectiveness and functionality deteriorate

Engineering Contradiction:

Improvetissue regenerationVSAvoidintegration effectiveness

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The implant incorporates cells and growth factors at specific locations within the physical matrix structure, creating local zones of high regenerative activity. This localized distribution ensures that tissue regeneration occurs where needed while maintaining overall integration effectiveness, as the matrix structure guides and contains the regenerative processes.

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

Cells and growth factors are pre-integrated into the physical matrix before implantation, allowing them to be immediately available for tissue regeneration upon implantation. This preliminary integration ensures that the regenerative components are properly positioned and stabilized within the matrix, preventing loss or misplacement that would reduce integration effectiveness.

Inventive Principle:

Principle #10Preliminary action

Data Source

PatentUS8834928B1Tissue-derived tissugenic implants, and methods of fabricating and using same

Publication Date: 2014.09.16 MUSCULOSKELETAL TRANSPLANT FOUND INC

AI summary

The disclosure provides implants containing a plurality of particles containing at least one population of viable tissuegenic cells adherent to and resident in the growth-conductive matrix or at least viable population of tissuegenic cells caused to be in contact with the growth-conductive matrix; methods to fabricate implants; methods of fabricating the implants; and use of the implants in tissue repair.